Wikidata

(Q21172758)

English

Eukaryotic translation initiation factor 2 alpha kinase 3

mammalian protein found in Homo sapiens

  • eukaryotic translation initiation factor 2-alpha kinase 3
  • HsPEK
  • PRKR-like endoplasmic reticulum kinase
  • EIF2AK3
  • pancreatic EIF2-alpha kinase
In more languages

Statements

molecular function
protein binding
determination method
IPI
5 references
retrieved
8 April 2019
stated in
TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IPI
retrieved
8 April 2019
stated in
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IPI
retrieved
8 April 2019
stated in
TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IPI
retrieved
8 April 2019
stated in
Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IPI
retrieved
8 April 2019
stated in
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IPI
eukaryotic translation initiation factor 2alpha kinase activity
determination method
IDA
IEA
IMP
6 references
retrieved
26 September 2017
stated in
p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5
determination method
IMP
retrieved
26 September 2017
stated in
Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5
determination method
IMP
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5
determination method
IEA
retrieved
26 September 2017
stated in
Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5
determination method
IDA
retrieved
26 September 2017
stated in
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5
determination method
IDA
retrieved
26 September 2017
stated in
Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5
determination method
IDA
eukaryotic translation initiation factor 2alpha kinase activity
determination method
IBA
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IMP
retrieved
8 April 2019
stated in
p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IEA
retrieved
8 April 2019
stated in
Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IDA
retrieved
8 April 2019
stated in
Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IDA
retrieved
8 April 2019
stated in
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
GOA
curator
UniProt
UniProt protein ID
Q9NZJ5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5
determination method
IBA
cell component
biological process

Identifiers

 
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