(Q24292499)

English

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

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scholarly article

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Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress (English)

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endoplasmic reticulum

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molecular chaperones

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Eukaryotic translation initiation factor 2 alpha kinase 3

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GOA release 2020-03-11

protein autophosphorylation

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GOA release 2020-03-11

author name string

Kun Ma

1

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Krishna M Vattem

2

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Ronald C Wek

3

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language of work or name

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publication date

24 May 2002

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Journal of Biological Chemistry

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277

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21

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18728-35

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eIF-2 kinases: regulators of general and gene-specific translation initiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

PKR: a new name and new roles.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Double-stranded RNA-activated protein kinase mediates virus-induced apoptosis: a new role for an old actor

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https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

PKR; a sentinel kinase for cellular stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Regulated translation initiation controls stress-induced gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Perk is essential for translational regulation and cell survival during the unfolded protein response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Dual role for Hsc70 in the biogenesis and regulation of the heme-regulated kinase of the alpha subunit of eukaryotic translation initiation factor 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Characterization of phosphopeptides from protein digests using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nanoelectrospray quadrupole time-of-flight mass spectrometry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

The unfolded protein response: an intracellular signalling pathway with many surprising features

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Homocysteine-dependent alterations in mitochondrial gene expression, function and structure. Homocysteine and H2O2 act synergistically to enhance mitochondrial damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Mechanism of interferon action. Biochemical and genetic evidence for the intermolecular association of the RNA-dependent protein kinase PKR from human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

21 January 2018

Overview of protein trafficking in the secretory and endocytic pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

7 January 2021

based on heuristic

inferred from DOI database lookup

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

7 January 2021

based on heuristic

inferred from DOI database lookup

Wolcott-Rallison syndrome: a case with endocrine and exocrine pancreatic deficiency and pancreatic hypotrophy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of translational initiation during cellular responses to stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence that Hsc70 negatively modulates the activation of the heme-regulated eIF-2alpha kinase in rabbit reticulocyte lysate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

7 January 2021

based on heuristic

inferred from DOI database lookup

Ribosome targeting of PKR is mediated by two double-stranded RNA-binding domains and facilitates in vivo phosphorylation of eukaryotic initiation factor-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200903200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M200903200

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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