(Q21173406)

Ureohydrolase domain superfamily

1 reference

Histone deacetylase, subgroup

1 reference

inferred from protein domain or family

histone deacetylases

1 reference

based on heuristic

1 reference

18 July 2018

1 reference

18 July 2018

Hsp90 protein binding

1 reference

8 April 2019

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

NAD-dependent histone deacetylase activity (H3-K14 specific)

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

histone deacetylase activity

5 references

27 February 2018

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

27 February 2018

Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

Hsp70 protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

histone deacetylase activity

6 references

8 April 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

8 April 2019

Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

transcription factor binding

1 reference

8 April 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

histone deacetylase complex

TAS

cell component

1 reference

27 February 2018

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

1 reference

8 April 2019

Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

histone H3 deacetylation

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

regulation of transcription, DNA-templated

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

regulation of protein stability

1 reference

8 April 2019

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

regulation of telomere maintenance

IDA

1 reference

8 April 2019

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

negative regulation of transcription by RNA polymerase II

IMP

1 reference

8 April 2019

Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

transcription, DNA-templated

TAS

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

sister chromatid cohesion

1 reference

8 April 2019

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

regulation of cohesin loading

IMP

1 reference

8 April 2019

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

negative regulation of protein ubiquitination

IMP

1 reference

8 April 2019

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

IDA

histone deacetylation

1 reference

8 April 2019

negative regulation of gene expression

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

cellular response to trichostatin A

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

negative regulation of osteoblast differentiation

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

cellular response to forskolin

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

negative regulation of histone H3-K9 acetylation

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BY41&geneProductId=UniProtKB:Q9BY41

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

histone H3 deacetylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

histone H4 deacetylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BY41

physically interacts with

1 reference

7495

17 August 2016

1 reference

7496

17 August 2016

1 reference

1059

17 August 2016

1 reference

7490

17 August 2016

1 reference

7489

17 August 2016

1 reference

7503

17 August 2016

1 reference

7502

17 August 2016

1 reference

7006

17 August 2016

1 reference

7005

17 August 2016

1 reference

6852

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL27759

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL598797

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3622533

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL235191

has part(s)

Histone deacetylase domain

1 reference

Identifiers

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

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18 May 2018

1 reference

6 April 2018

1 reference

18 July 2018

1 reference

1 reference

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016