(Q21428395)

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox domain, metazoa, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

2 references

sequence-specific DNA binding

3 references

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

24 April 2018

Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

DNA-binding transcription factor activity

1 reference

14 February 2019

Homeobox protein Hex induces SMemb/nonmuscle myosin heavy chain-B gene expression through the cAMP-responsive element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors

HMG box domain binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

1 reference

14 February 2019

Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

DNA-binding transcription repressor activity, RNA polymerase II-specific

1 reference

24 April 2018

Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

RNA polymerase II transcription regulatory region sequence-specific DNA binding

IBA

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

DNA-binding transcription repressor activity, RNA polymerase II-specific

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

DNA-binding transcription repressor activity, RNA polymerase II-specific

IBA

transcription factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

eukaryotic initiation factor 4E binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

protein homodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

DNA-binding transcription repressor activity, RNA polymerase II-specific

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

HEX expression and localization in normal mammary gland and breast carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

Immunocytochemical characterization of murine Hex, a homeobox-containing protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

HEX expression and localization in normal mammary gland and breast carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

Immunocytochemical characterization of murine Hex, a homeobox-containing protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

HEX expression and localization in normal mammary gland and breast carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

biological process

Notch signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

myeloid leukocyte differentiation

1 reference

14 February 2019

Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

1 reference

14 February 2019

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

primary lung bud formation

IEA

1 reference

14 February 2019

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

multicellular organism growth

1 reference

14 February 2019

Correct patterning of the primitive streak requires the anterior visceral endoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

embryonic organ development

1 reference

14 February 2019

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Correct patterning of the primitive streak requires the anterior visceral endoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

negative regulation of vascular endothelial growth factor receptor signaling pathway

1 reference

14 February 2019

HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

interkinetic nuclear migration

1 reference

14 February 2019

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

hepatocyte differentiation

1 reference

14 February 2019

Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

in utero embryonic development

1 reference

14 February 2019

Correct patterning of the primitive streak requires the anterior visceral endoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

negative regulation of transcription by RNA polymerase II

6 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

Wnt signaling pathway

1 reference

14 February 2019

1 reference

14 February 2019

Correct patterning of the primitive streak requires the anterior visceral endoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

embryonic heart tube development

IEA

1 reference

14 February 2019

A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

morphogenesis of an epithelium

1 reference

14 February 2019

The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

positive regulation of Wnt signaling pathway

IEA

1 reference

14 February 2019

Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

Correct patterning of the primitive streak requires the anterior visceral endoderm

forebrain morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

hepatoblast differentiation

1 reference

14 February 2019

The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

common bile duct development

1 reference

14 February 2019

The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

regulation of cell population proliferation

1 reference

14 February 2019

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

animal organ morphogenesis

1 reference

14 February 2019

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

negative regulation of angiogenesis

1 reference

14 February 2019

HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

1 reference

14 February 2019

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis

gall bladder development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

4 references

14 February 2019

Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

forebrain development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

Getting your head around Hex and Hesx1: forebrain formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis

hepatic duct development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

negative regulation of transcription, DNA-templated

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

24 April 2018

Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

1 reference

14 February 2019

Correct patterning of the primitive streak requires the anterior visceral endoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

anterior/posterior pattern specification

1 reference

14 February 2019

Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

response to peptide hormone

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

negative regulation of transcription by RNA polymerase II

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

IBA

mRNA export from nucleus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

cell population proliferation

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43120&geneProductId=UniProtKB:P43120

poly(A)+ mRNA export from nucleus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

3 references

protein localization to nucleus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

negative regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

DNA conformation change

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

regulation of leukocyte proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43120

has part(s)

Homeobox, conserved site

1 reference

Homeobox domain, metazoa

1 reference

Homeobox domain

1 reference