(Q21436500)

hereditary hemochromatosis protein

1 reference

Immunoglobulin-like domain superfamily

1 reference

MHC classes I/II-like antigen recognition protein

1 reference

MHC class I-like antigen recognition-like superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

MHC class I-like antigen recognition-like, protein family

1 reference

Immunoglobulin C1-set, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Immunoglobulin/major histocompatibility complex, conserved site, protein family

1 reference

MHC class I alpha chain, alpha1 alpha2 domains, protein family

1 reference

transferrin receptor binding

1 reference

25 May 2022

1 reference

25 May 2022

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

1 January 2018

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

natural killer cell lectin-like receptor binding

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

transferrin receptor binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

integral component of membrane

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

HFE-transferrin receptor complex

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

3 references

external side of plasma membrane

3 references

negative regulation of T cell antigen processing and presentation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

response to iron ion starvation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

Multigenic control of hepatic iron loading in a murine model of hemochromatosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

cellular response to iron ion starvation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

multicellular organismal iron ion homeostasis

1 reference

14 February 2019

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

positive regulation of gene expression

1 reference

14 February 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

14 February 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

negative regulation of ubiquitin-dependent protein catabolic process

IC

3 references

hormone biosynthetic process

1 reference

14 February 2019

Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70387

iron ion import across plasma membrane

IMP

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

24 April 2018

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

T cell mediated cytotoxicity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

natural killer cell activation

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

natural killer cell mediated cytotoxicity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

susceptibility to natural killer cell mediated cytotoxicity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

iron ion import across plasma membrane

5 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

7 November 2018

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

iron ion import across plasma membrane

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70387&geneProductId=UniProtKB:P70387

immunoglobulin-like domain

has part(s)

1 reference

immunoglobulin C1-set

1 reference

MHC class I alpha chain, alpha1 alpha2 domains

1 reference

MHC class I-like antigen recognition-like

1 reference

Immunoglobulin/major histocompatibility complex, conserved site

1 reference