(Q21491045)

Protein kinase-like domain superfamily

1 reference

protein kinase C, epsilon

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Protein kinase, C-terminal domain, protein family

1 reference

C2 domain, protein family

1 reference

Diacylglycerol/phorbol-ester binding domain, protein family

1 reference

AGC-kinase, C-terminal domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Novel protein kinase C epsilon, catalytic domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

protein kinase C activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

actin monomer binding

1 reference

8 April 2019

Biochemical and morphogenic effects of the interaction between protein kinase C-epsilon and actin in vitro and in cultured NIH3T3 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

14-3-3 protein binding

1 reference

8 April 2019

The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

signaling receptor activator activity

1 reference

8 April 2019

Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

protein serine/threonine kinase activity

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16054&geneProductId=UniProtKB:P16054

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16054&geneProductId=UniProtKB:P16054

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16054&geneProductId=UniProtKB:P16054

5 June 2018

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16054&geneProductId=UniProtKB:P16054

5 June 2018

Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16054&geneProductId=UniProtKB:P16054

protein binding

7 references

8 April 2019

The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

Interaction of connexin43 and protein kinase C-delta during FGF2 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

A 20-amino acid module of protein kinase C{epsilon} involved in translocation and selective targeting at cell-cell contacts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

ethanol binding

1 reference

8 April 2019

PKC epsilon has an alcohol-binding site in its second cysteine-rich regulatory domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

signaling receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

SH3 domain binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

protein serine/threonine kinase activity

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

IBA

cell component

cytoplasm

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

cytosol

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

Golgi apparatus

1 reference

8 April 2019

Phosphorylation at Ser729 specifies a Golgi localisation for protein kinase C epsilon (PKCepsilon) in 3T3 fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

3 references

8 April 2019

8 April 2019

PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

plasma membrane

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

cell periphery

1 reference

8 April 2019

Phosphorylation at Ser729 specifies a Golgi localisation for protein kinase C epsilon (PKCepsilon) in 3T3 fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

mitochondrion

1 reference

8 April 2019

Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

Golgi membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

T-tubule

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

neuromuscular junction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

presynaptic cytosol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

release of sequestered calcium ion into cytosol

biological process

1 reference

14 February 2019

Cross-desensitization among CXCR1, CXCR2, and CCR5: role of protein kinase C-epsilon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

8 April 2019

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

positive regulation of actin filament polymerization

1 reference

8 April 2019

Biochemical and morphogenic effects of the interaction between protein kinase C-epsilon and actin in vitro and in cultured NIH3T3 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

cellular response to ethanol

1 reference

8 April 2019

Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

regulation of release of sequestered calcium ion into cytosol

1 reference

14 February 2019

Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

positive regulation of lipid catabolic process

1 reference

8 April 2019

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

positive regulation of wound healing

ISS

positive regulation of epithelial cell migration

ISS

positive regulation of synaptic transmission, GABAergic

1 reference

8 April 2019

Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

TRAM-dependent toll-like receptor 4 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

positive regulation of cytokinesis

ISS

locomotory exploration behavior

1 reference

8 April 2019

Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

chemosensory behavior

TAS

1 reference

8 April 2019

Ethanol consumption and behavioral impulsivity are increased in protein kinase Cgamma null mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

negative regulation of protein ubiquitination

TAS

1 reference

8 April 2019

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

protein phosphorylation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

macrophage activation involved in immune response

1 reference

8 April 2019

Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

regulation of lipid metabolic process

1 reference

8 April 2019

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

response to morphine

1 reference

8 April 2019

Increased response to morphine in mice lacking protein kinase C epsilon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

cellular response to prostaglandin E stimulus

1 reference

8 April 2019

Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

peptidyl-serine phosphorylation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

positive regulation of I-kappaB kinase/NF-kappaB signaling

IBA

1 reference

8 April 2019

Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

cell division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

1 reference

8 April 2019

positive regulation of mucus secretion

1 reference

8 April 2019

nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

positive regulation of fibroblast migration

1 reference

8 April 2019

PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

cellular response to hypoxia

1 reference

8 April 2019

Protein kinase C epsilon activates lens mitochondrial cytochrome c oxidase subunit IV during hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

lipopolysaccharide-mediated signaling pathway

positive regulation of MAPK cascade

Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

8 April 2019

Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

positive regulation of insulin secretion

1 reference

8 April 2019

Involvement of protein kinase C-epsilon in inositol hexakisphosphate-induced exocytosis in mouse pancreatic beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

positive regulation of cell-substrate adhesion

positive regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

positive regulation of catalytic activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

negative regulation of mitochondrial membrane potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

cellular response to platelet-derived growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

negative regulation of release of sequestered calcium ion into cytosol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

negative regulation of mitochondrial calcium ion concentration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

intracellular signal transduction

IBA

regulation of synaptic vesicle exocytosis

3 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16054

regulation of release of sequestered calcium ion into cytosol

diacylglycerol/phorbol-ester binding

has part(s)

1 reference

AGC-kinase, C-terminal

1 reference

serine/threonine-protein kinase, active site

1 reference

protein kinase, C-terminal

1 reference

protein kinase, ATP binding site

1 reference

C2 domain

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

protein kinase domain

1 reference

Novel protein kinase C epsilon, catalytic domain

1 reference