(Q28205242)

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Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity

scientific article (publication date: 28 March 2003)

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scholarly article

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Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity (English)

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Troponin I, cardiac 3

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GOA release 2020-03-11

Protein kinase C, epsilon

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GOA release 2020-03-11

phosphorylation

1 reference

based on heuristic

inferred from title

author name string

Eileen M Burkart

1

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Marius P Sumandea

2

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Tomoyoshi Kobayashi

3

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Mahta Nili

4

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Anne F Martin

5

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Earl Homsher

6

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R John Solaro

7

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language of work or name

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publication date

28 March 2003

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Journal of Biological Chemistry

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278

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13

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11265-72

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1 reference

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Integration of cardiac myofilament activity and regulation with pathways signaling hypertrophy and failure

1 reference

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1 reference

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1 reference

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Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants

1 reference

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1 reference

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Altered interactions among thin filament proteins modulate cardiac function

1 reference

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Phosphorylation of both serine residues in cardiac troponin I is required to decrease the Ca2+ affinity of cardiac troponin C.

1 reference

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Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.

1 reference

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alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI.

1 reference

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Troponin I serines 43/45 and regulation of cardiac myofilament function

1 reference

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Characterization of protein kinase C isotype expression in adult rat heart. Protein kinase C-epsilon is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin

1 reference

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Influence of temperature upon contractile activation and isometric force production in mechanically skinned muscle fibers of the frog

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1 reference

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Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033

1 reference

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A pH-sensitive interaction of troponin I with troponin C coupled with strongly binding cross-bridges in cardiac myofilament activation

1 reference

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The variation in isometric tension with sarcomere length in vertebrate muscle fibres

1 reference

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Altered cardiac troponin T in vitro function in the presence of a mutation implicated in familial hypertrophic cardiomyopathy

1 reference

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Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties

1 reference

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21 January 2018

Role of protein kinase C in the phosphorylation of cardiac myosin light chain 2

1 reference

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Phosphorylation of troponin I controls cardiac twitch dynamics: evidence from phosphorylation site mutants expressed on a troponin I-null background in mice

1 reference

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21 January 2018

Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy

1 reference

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In vitro motility analysis of thin filaments from failing and non-failing human heart: troponin from failing human hearts induces slower filament sliding and higher Ca(2+) sensitivity

1 reference

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In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts

1 reference

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Protein kinase C inhibitors as novel anticancer drugs

1 reference

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Steric-blocking by Tropomyosin Visualized in Relaxed Vertebrate Muscle Thin Filaments

1 reference

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Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart

1 reference

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21 January 2018

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