(Q21491046)

http://www.ebi.ac.uk/interpro/protein/P22893

Zinc finger, CCCH-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

IEA

C-C chemokine binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

6 references

8 April 2019

Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

mRNA 3'-UTR AU-rich region binding

IPI

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Modulation of immediate early gene expression by tristetraprolin in the differentiation of 3T3-L1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

4 references

8 April 2019

Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

ISO

14-3-3 protein binding

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

heat shock protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1

ISO

RNA polymerase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22893&geneProductId=UniProtKB:P22893

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

exosome (RNase complex)

1 reference

8 April 2019

1 reference

8 April 2019

MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

2 references

5 June 2018

Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22893&geneProductId=UniProtKB:P22893

5 June 2018

Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22893&geneProductId=UniProtKB:P22893

ribonucleoprotein complex

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Modulation of immediate early gene expression by tristetraprolin in the differentiation of 3T3-L1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

3 references

8 April 2019

Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

intracellular signal transduction

IBA

biological process

1 reference

8 April 2019

Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

mRNA catabolic process

3 references

8 April 2019

8 April 2019

Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

1 reference

8 April 2019

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

miRNA-mediated gene silencing by inhibition of translation

IGI

1 reference

8 April 2019

Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

negative regulation of myeloid cell differentiation

1 reference

8 April 2019

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

negative regulation of inflammatory response

3 references

8 April 2019

Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

1 reference

8 April 2019

Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

regulation of mRNA stability

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

cellular response to tumor necrosis factor

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

positive regulation of fat cell differentiation

1 reference

8 April 2019

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

positive regulation of mRNA catabolic process

1 reference

8 April 2019

Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

cellular response to fibroblast growth factor stimulus

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

3'-UTR-mediated mRNA destabilization

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22893&geneProductId=UniProtKB:P22893

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22893&geneProductId=UniProtKB:P22893

5 June 2018

Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22893&geneProductId=UniProtKB:P22893

5 June 2018

Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22893&geneProductId=UniProtKB:P22893

5 June 2018

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22893&geneProductId=UniProtKB:P22893

cellular response to lipopolysaccharide

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

negative regulation of polynucleotide adenylyltransferase activity

1 reference

8 April 2019

Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

3'-UTR-mediated mRNA destabilization

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893

IBA

has part(s)

Zinc finger, CCCH-type

1 reference

stated in

InterPro Release 71.0