(Q21493994)

Protein kinase-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Diacylglycerol/phorbol-ester binding domain, protein family

1 reference

Raf-like Ras-binding domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

5 references

14 February 2019

Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

ERK and PDE4 cooperate to induce RAF isoform switching in melanoma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

2 references

protein kinase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

IQGAP1 modulates activation of B-Raf

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

protein serine/threonine kinase activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

identical protein binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

MAP kinase kinase kinase activity

mitogen-activated protein kinase kinase binding

protein serine/threonine kinase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

14 February 2019

Cortical migration defects in mice expressing A-RAF from the B-RAF locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

24 April 2018

Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

intracellular membrane-bounded organelle

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

3 references

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

24 April 2018

Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

3 references

3 references

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

14 February 2019

Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

CD4-positive, alpha-beta T cell differentiation

1 reference

14 February 2019

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

14 February 2019

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

regulation of axon regeneration

1 reference

14 February 2019

B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

negative regulation of endothelial cell apoptotic process

1 reference

14 February 2019

Endothelial apoptosis in Braf-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

negative regulation of fibroblast migration

1 reference

14 February 2019

B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

intracellular signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

14 February 2019

B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

myeloid progenitor cell differentiation

1 reference

14 February 2019

A critical function for B-Raf at multiple stages of myelopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

somatic stem cell population maintenance

1 reference

14 February 2019

B-Raf and C-Raf are required for melanocyte stem cell self-maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

14 February 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

positive regulation of axon regeneration

1 reference

14 February 2019

B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

positive T cell selection

1 reference

14 February 2019

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

negative regulation of synaptic vesicle exocytosis

1 reference

14 February 2019

Rap1 signaling prevents L-type calcium channel-dependent neurotransmitter release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

positive regulation of substrate adhesion-dependent cell spreading

1 reference

14 February 2019

B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

thyroid gland development

1 reference

14 February 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

14 February 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

regulation of cell population proliferation

1 reference

14 February 2019

STAT3 negatively regulates thyroid tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

alpha-beta T cell differentiation

1 reference

14 February 2019

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory

IEA

long-term potentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

protein phosphorylation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

IQGAP1 modulates activation of B-Raf

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

positive regulation of ERK1 and ERK2 cascade

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

B-Raf-mediated signaling pathway regulates T cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

A critical function for B-Raf at multiple stages of myelopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

Rap1 signaling prevents L-type calcium channel-dependent neurotransmitter release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

negative regulation of signal transduction

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

IBA

1 reference

14 February 2019

B-Raf-mediated signaling pathway regulates T cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

regulation of T cell differentiation

1 reference

14 February 2019

B-Raf-mediated signaling pathway regulates T cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

T cell receptor signaling pathway

1 reference

14 February 2019

B-Raf-mediated signaling pathway regulates T cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

cellular response to nerve growth factor stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

positive regulation of glucose transmembrane transport

IEA

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

positive regulation of peptidyl-serine phosphorylation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

negative regulation of apoptotic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

trehalose metabolism in response to stress

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

cellular response to calcium ion

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

establishment of protein localization to membrane

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

negative regulation of neuron apoptotic process

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028

positive regulation of gene expression

IBA

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028

diacylglycerol/phorbol-ester binding

IBA

has part(s)

1 reference

Raf-like Ras-binding

1 reference

serine/threonine-protein kinase, active site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

protein kinase domain

1 reference