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The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway
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PubMed
PubMed ID
22892241
retrieved
25 January 2017
title
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway
(English)
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PubMed
PubMed ID
22892241
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25 January 2017
main subject
Braf transforming gene
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GOA release 2020-03-11
author
Pearl Lee
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Pearl Lee
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8
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Richard Marais
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Richard Marais
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Catrin Pritchard
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Catrin Pritchard
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12
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Catherine Andreadi
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1
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PubMed
PubMed ID
22892241
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25 January 2017
Lai-Kay Cheung
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2
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PubMed
PubMed ID
22892241
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25 January 2017
Susan Giblett
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3
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PubMed
PubMed ID
22892241
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25 January 2017
Bipin Patel
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4
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PubMed
PubMed ID
22892241
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25 January 2017
Hong Jin
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5
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PubMed
PubMed ID
22892241
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25 January 2017
Kathryn Mercer
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6
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PubMed
PubMed ID
22892241
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25 January 2017
Tamihiro Kamata
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7
1 reference
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PubMed
PubMed ID
22892241
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25 January 2017
Alexander Williams
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9
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PubMed
PubMed ID
22892241
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25 January 2017
Martin McMahon
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10
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PubMed
PubMed ID
22892241
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25 January 2017
publication date
1 September 2012
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PubMed
PubMed ID
22892241
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25 January 2017
published in
Genes & Development
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PubMed
PubMed ID
22892241
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25 January 2017
volume
26
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PubMed
PubMed ID
22892241
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25 January 2017
issue
17
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PubMed
PubMed ID
22892241
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25 January 2017
page(s)
1945–1958
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PubMed
PubMed ID
22892241
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25 January 2017
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Europe PubMed Central
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11 June 2022
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https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3435497/fullTextXML
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limma
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Europe PubMed Central
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22 June 2022
reference URL
https://europepmc.org/article/PMC/3435497
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cites work
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
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PubMed Central
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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
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19 March 2017
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435497
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19 March 2017
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435497
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19 March 2017
The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435497
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19 March 2017
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
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19 March 2017
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PubMed Central
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retrieved
19 March 2017
Bioconductor: open software development for computational biology and bioinformatics
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PubMed Central
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retrieved
19 March 2017
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435497
retrieved
19 March 2017
Mutations of the BRAF gene in human cancer
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435497
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19 March 2017
MEK kinase activity is not necessary for Raf-1 function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435497
retrieved
19 March 2017
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435497
retrieved
7 April 2017
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
1 reference
stated in
PubMed Central
reference URL
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7 April 2017
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435497
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1 reference
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RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
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PubMed Central
reference URL
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1 reference
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PubMed Central
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1 reference
stated in
PubMed Central
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Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies
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1 reference
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Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma
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PubMed Central
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29 September 2017
Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors
1 reference
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PubMed Central
reference URL
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29 September 2017
(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435497
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29 September 2017
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PubMed Central
reference URL
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PubMed Central
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In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling
1 reference
stated in
PubMed Central
reference URL
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1 reference
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PubMed Central
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PubMed Central
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2 June 2018
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PubMed Central
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Effects of germline mutations in the Ras/MAPK signaling pathway on adaptive behavior: cardiofaciocutaneous syndrome and Noonan syndrome.
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reference URL
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1 reference
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27 November 2018
Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome
1 reference
stated in
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reference URL
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1 reference
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1 reference
stated in
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27 November 2018
Genetic Interactions in Cancer Progression and Treatment
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22892241
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22892241
retrieved
12 December 2020
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Identifiers
DOI
10.1101/GAD.193458.112
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3932139
OpenCitations bibliographic resource ID
3932139
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3932139
PMCID
3435497
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3932139
PubMed ID
22892241
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3932139
ResearchGate publication ID
230670679
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