(Q29615032)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21107320

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Alexandria P. Cogdill

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Jordi Barretina Ginesta

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Kourosh Salehi-Ashtiani

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

35

Levi A Garraway

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

27

Todd Golub

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

34

William C Hahn

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

25

David E Root

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

16

Marc Vidal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

15

David E Hill

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

13

Ryan R Murray

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1

Cory M Johannessen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

4

Sapana R Thomas

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

12

Haley Hieronymus

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

19

Ozan Alkan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

33

Jennifer A Wargo

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

29

Reinhard Dummer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

So Young Kim

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Leslie Wardwell

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Laura A Johnson

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Caroline M Emery

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Nicolas Stransky

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Giordano Caponigro

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Jean J Zhao

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Xiaoping Yang

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Sungjoon Kim

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Jennifer L Harris

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Christopher J Wilson

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Vic E Myer

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Peter M Finan

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Thomas M Roberts

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Keith T Flaherty

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Barbara L Weber

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

William R Sellers

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Robert Schlegel

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21107320

17 January 2020

language of work or name

1 reference

30 April 2017

publication date

24 November 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21107320

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

468

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21107320

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

7326

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21107320

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

968-972

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

17 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

The landscape of somatic copy-number alteration across human cancers

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

MEK1 mutations confer resistance to MEK and B-RAF inhibition

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

BRAF mutation predicts sensitivity to MEK inhibition

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Mutations of the BRAF gene in human cancer

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Inhibition of tumor progression locus 2 protein kinase suppresses receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis through down-regulation of the c-Fos and nuclear factor of activated T cells c1 genes

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Tpl2 is a key mediator of arsenite-induced signal transduction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the Ras/Raf signalling pathway in advanced colorectal cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Integrative genomic approaches identify IKBKE as a breast cancer oncogene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Strategies to overcome resistance to targeted protein kinase inhibitors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

V599EB-RAF is an oncogene in melanocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

Immortalization and transformation of primary human airway epithelial cells by gene transfer.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058384

NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing.

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE09627

Discovery of thieno[2,3-c]pyridines as potent COT inhibitors

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21107320

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/21107320

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

3 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21107320

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 January 2020

1005907434

0 references

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21107320

3 references

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21107320%20AND%20SRC:MED&resulttype=core&format=json

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21107320

17 January 2020

PubMed publication ID

3 references

30 April 2017