(Q33431755)

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Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors

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Europe PubMed Central

PubMed publication ID

26 July 2017

Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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object named as

Richard Marais

3

0 references

E. Elizabeth Patton

5

object named as

E Elizabeth Patton

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

author name string

Corina Anastasaki

1

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Anne L Estep

2

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Katherine A Rauen

4

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

publication date

17 April 2009

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Europe PubMed Central

PubMed publication ID

26 July 2017

Human Molecular Genetics

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Europe PubMed Central

PubMed publication ID

26 July 2017

18

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

14

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

2543-2554

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Noonan, Costello and cardio-facio-cutaneous syndromes: dysregulation of the Ras-MAPK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

High-resolution in situ hybridization to whole-mount zebrafish embryos

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Mouse models for BRAF-induced cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

The INT6 cancer gene and MEK signaling pathways converge during zebrafish development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Melanoma biology and new targeted therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Mechanisms of drug inhibition of signalling molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Stops along the RAS pathway in human genetic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Regulation and role of Raf-1/B-Raf heterodimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

BRAF mutation predicts sensitivity to MEK inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Conserved patterns of cell movements during vertebrate gastrulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

In vivo drug discovery in the zebrafish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Targeting the mitogen-activated protein kinase cascade to treat cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

High frequency of BRAF mutations in nevi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Mutations of the BRAF gene in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

The art and design of genetic screens: zebrafish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701326

21 June 2018

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP186

21 January 2018

Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP186

21 January 2018

Headwaters of the zebrafish -- emergence of a new model vertebrate

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP186

21 January 2018

Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP186

21 January 2018

Fgf signalling controls the dorsoventral patterning of the zebrafish embryo

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP186

21 January 2018

Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP186

21 January 2018

Biochemical characterization of novel germline BRAF and MEK mutations in cardio-facio-cutaneous syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP186

21 January 2018

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP186

21 January 2018

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP186

21 January 2018

Cancer drugs to treat birth defects

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP186

21 January 2018

RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP186

21 January 2018

Distinguishing Costello versus cardio-facio-cutaneous syndrome: BRAF mutations in patients with a Costello phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/19376813

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007

1 reference

https://pubmed.ncbi.nlm.nih.gov/19376813

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/HMG/DDP186

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

ResearchGate publication ID

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