(Q36028226)

11 August 2017

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title

In vivo drug discovery in the zebrafish (English)

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11 August 2017

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Leonard I Zon

1

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PubMed ID

15688071

11 August 2017

Randall T Peterson

series ordinal

2

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11 August 2017

1 January 2005

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Nature Reviews Drug Discovery

11 August 2017

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11 August 2017

4

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11 August 2017

35-44

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11 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrd1606

11 August 2017

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cites work

Zebrafish make a big splash

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Rapid mapping of zebrafish mutations with SNPs and oligonucleotide microarrays

31 March 2020

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Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development

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Effective targeted gene 'knockdown' in zebrafish

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Morpholino oligos: making sense of antisense?

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Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon.

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Transgenic zebrafish produced by retroviral infection of in vitro-cultured sperm.

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Target-selected inactivation of the zebrafish rag1 gene

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Cloned zebrafish by nuclear transfer from long-term-cultured cells

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Cyclic AMP-induced repair of zebrafish spinal circuits

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Genetic analysis of digestive physiology using fluorescent phospholipid reporters.

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Hit and lead generation: beyond high-throughput screening

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From Zebrafish to human: modular medical models

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Zebrafish as a cancer model system

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Identification of 315 genes essential for early zebrafish development

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A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney.

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Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination

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Tales of regeneration in zebrafish.

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Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.

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Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin.

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Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

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A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

31 March 2020

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Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia

31 March 2020

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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

31 March 2020

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A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis

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cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes

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Myc-induced T cell leukemia in transgenic zebrafish.

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A dominant form of inherited retinal degeneration caused by a non-photoreceptor cell-specific mutation

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Modulation of the histaminergic system and behaviour by alpha-fluoromethylhistidine in zebrafish

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Genetic analysis of vertebrate sensory hair cell mechanosensation: the zebrafish circler mutants.

31 March 2020

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Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish.

31 March 2020

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Behavioral screening for cocaine sensitivity in mutagenized zebrafish

31 March 2020

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Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

31 March 2020

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Pilot morpholino screen in Xenopus tropicalis identifies a novel gene involved in head development

31 March 2020

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Morpholino-based gene knockdown screen of novel genes with developmental function in Ciona intestinalis

31 March 2020

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Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

31 March 2020

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The discovery of ezetimibe: a view from outside the receptor

31 March 2020

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Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

31 March 2020

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Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation.

31 March 2020

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Cancer genetics and drug discovery in the zebrafish

31 March 2020

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gridlock, an HLH gene required for assembly of the aorta in zebrafish

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Gridlock signalling pathway fashions the first embryonic artery

31 March 2020

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In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish

31 March 2020

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Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation

31 March 2020

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Heart regeneration in zebrafish

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Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish?

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Toxicogenomics and drug discovery: will new technologies help us produce better drugs?

31 March 2020

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Toward the design of chemical libraries for mass screening biased against mutagenic compounds

31 March 2020

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Making better drugs: Decision gates in non-clinical drug development

31 March 2020

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Zebrafish: a preclinical model for drug screening

31 March 2020

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Impacts of 17beta-estradiol, including environmentally relevant concentrations, on reproduction after exposure during embryo-larval-, juvenile- and adult-life stages in zebrafish (Danio rerio).

31 March 2020

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Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination

31 March 2020

1 reference

Origins of anteroposterior patterning and Hox gene regulation during chordate evolution

31 March 2020

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Neoplasia in zebrafish (Danio rerio) treated with 7,12-dimethylbenz[a]anthracene by two exposure routes at different developmental stages.

31 March 2020

1 reference

Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio).

31 March 2020

1 reference

Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments.

31 March 2020

1 reference

Drugs that induce repolarization abnormalities cause bradycardia in zebrafish

31 March 2020

1 reference

Zebrafish: a new model on the pharmaceutical catwalk

31 March 2020

1 reference

First dose of potential new medicines to humans: how animals help

31 March 2020

1 reference

Insertional mutagenesis in zebrafish

31 March 2020

1 reference

Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates

31 March 2020

1 reference

Radiation hybrid mapping of the zebrafish genome

31 March 2020

1 reference

A radiation hybrid map of the zebrafish genome.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1606

1 reference

11 August 2017

1 reference

PubMed ID

15688071