(Q35158006)

6 August 2017

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title

Making better drugs: Decision gates in non-clinical drug development (English)

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6 August 2017

J Fred Pritchard

1

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6 August 2017

Malle Jurima-Romet

2

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6 August 2017

Mark L J Reimer

3

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6 August 2017

Elisabeth Mortimer

4

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6 August 2017

Brenda Rolfe

5

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6 August 2017

Mitchell N Cayen

6

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6 August 2017

publication date

1 July 2003

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Nature Reviews Drug Discovery

6 August 2017

published in

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6 August 2017

volume

2

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6 August 2017

issue

7

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6 August 2017

page(s)

542-553

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Changes in plasma protein binding have little clinical relevance

6 August 2017

cites work

1 reference

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Cytochrome P-450 3A4: regulation and role in drug metabolism

31 March 2020

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Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia

31 March 2020

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HERG K(+) channel activity is regulated by changes in phosphatidyl inositol 4,5-bisphosphate

31 March 2020

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HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects

31 March 2020

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Toxicogenomics and drug discovery: will new technologies help us produce better drugs?

31 March 2020

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ADME/PK as part of a rational approach to drug discovery

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31 March 2020

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Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

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19F-NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4- trifluoromethylaniline in rat: a urinary excretion balance study without the use of radiolabelling

31 March 2020

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31 March 2020

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St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

31 March 2020

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

31 March 2020

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A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

31 March 2020

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31 March 2020

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An Introduction to Quadrupole Ion Trap Mass Spectrometry

31 March 2020

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An introduction to quadrupole-time-of-flight mass spectrometry

31 March 2020

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Liquid chromatography-nuclear magnetic resonance spectroscopy

31 March 2020

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Primary hepatocyte cultures as an in vitro experimental model for the evaluation of pharmacokinetic drug-drug interactions

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1131

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6 August 2017

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