(Q34378937)

1 August 2017

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title

High-throughput screening approaches for investigating drug metabolism and pharmacokinetics (English)

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1 August 2017

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S A Roberts

1

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1 August 2017

language of work or name

English

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publication date

1 August 2001

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1 August 2017

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1 August 2017

volume

31

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1 August 2017

issue

8-9

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1 August 2017

page(s)

557-589

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The correlation and prediction of the solubility of compounds in water using an amended solvation energy relationship.

1 August 2017

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Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

21 January 2018

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Role of transport proteins in drug absorption, distribution and excretion

21 January 2018

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Rapid assessment of drug metabolism in the drug discovery process

21 January 2018

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Accessing genetic information with high-density DNA arrays.

21 January 2018

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Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides

21 January 2018

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Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration

21 January 2018

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Assessing the potential for drug-drug interactions in an accelerated throughput mode

21 January 2018

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Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4.

21 January 2018

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Diversity measures for enhancing ADME admissibility of combinatorial libraries

21 January 2018

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CYP4A1 gene transfection studies and the peroxisome proliferator-activated receptor: development of a high-throughput assay to detect peroxisome proliferators

21 January 2018

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Analysis of Human Cytochrome P450 Catalytic Activities and Expression

21 January 2018

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Synthetic strategies to lower affinity for CYP2D6.

21 January 2018

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Microdialysis sampling for determination of plasma protein binding of drugs

21 January 2018

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Prediction of aqueous solubility for a diverse set of organic compounds based on atom-type electrotopological state indices.

21 January 2018

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MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

21 January 2018

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Predicting human safety: screening and computational approaches

21 January 2018

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Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1).

21 January 2018

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LASSOO: a generalized directed diversity approach to the design and enrichment of chemical libraries

21 January 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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Use of the nuclear receptor PXR to predict drug interactions

21 January 2018

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Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers

21 January 2018

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Theoretical calculation and prediction of brain-blood partitioning of organic solutes using MolSurf parametrization and PLS statistics

21 January 2018

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The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure

21 January 2018

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Methods of determining plasma and tissue binding of drugs. Pharmacokinetic consequences

21 January 2018

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Polar molecular surface properties predict the intestinal absorption of drugs in humans.

21 January 2018

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A rapid spectrofluorimetric technique for determining drug-serum protein binding suitable for high-throughput screening

21 January 2018

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IAM chromatography: an in vitro screen for predicting drug membrane permeability

21 January 2018

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Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)

21 January 2018

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The hydrophobic effect. 2. Relative importance of the hydrophobic effect on the solubility of hydrophobes and pharmaceuticals in H-bonded solvents.

21 January 2018

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A scoring scheme for discriminating between drugs and nondrugs.

21 January 2018

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A general pattern for substrate recognition by P-glycoprotein.

21 January 2018

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Ab initio molecular modeling in the study of drug metabolism

21 January 2018

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High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation.

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250110060978

Analysis of intestinal perfusion data for highly permeable drugs using a numerical aqueous resistance--nonlinear regression method.

21 January 2018

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High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds

21 January 2018

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Virtual screening—an overview

21 January 2018

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Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery

21 January 2018

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Prediction of human intestinal absorption of drug compounds from molecular structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

21 January 2018

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Use of transgenic animals in understanding molecular mechanisms of toxicity.

21 January 2018

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Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics

21 January 2018

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VolSurf: a new tool for the pharmacokinetic optimization of lead compounds

21 January 2018

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Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substrates

21 January 2018

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Simultaneous pharmacokinetic screening of a mixture of compounds in the dog using API LC/MS/MS analysis for increased throughput

21 January 2018

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Ultrafiltration vs equilibrium dialysis for determination of free fraction.

21 January 2018

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Evaluation of Biocoat intestinal epithelium differentiation environment (3-day cultured Caco-2 cells) as an absorption screening model with improved productivity

21 January 2018

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Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450

21 January 2018

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Novel approach to predicting P450-mediated drug metabolism: development of a combined protein and pharmacophore model for CYP2D6

21 January 2018

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ADME/PK as part of a rational approach to drug discovery

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250110060978

Prediction of drug absorption using multivariate statistics

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250110060978

A general, wide-rage spectrofluorometric method for measuring the site-specific affinities of drugs toward human serum albumin

21 January 2018

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Use and value of metabolism databases

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250110060978

Sample preparation for LC/MS/MS: analyzing biological and environmental samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Inhibition and induction of cytochrome P450 and the clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Proteomics: a major new technology for the drug discovery process

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Studies directed toward the design of orally active renin inhibitors. 1. Some factors influencing the absorption of small peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Molecular Determinants of Recognition for the Intestinal Peptide Carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Molecular modeling of cytochrome P450 3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Pharmacogenomics: the next logical step

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

Automated high throughput human CYP isoform activity assay using SPE-LC/MS method: application in CYP inhibition evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250110060978

10.1080/00498250110060978

21 January 2018

Identifiers

DOI

1 reference

1 August 2017

1 reference