(Q35697602)

9 August 2017

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title

First dose of potential new medicines to humans: how animals help (English)

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9 August 2017

Peter Greaves

1

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9 August 2017

Andrew Williams

series ordinal

2

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9 August 2017

Malcolm Eve

series ordinal

3

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9 August 2017

publication date

1 March 2004

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Nature Reviews Drug Discovery

9 August 2017

published in

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9 August 2017

volume

3

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9 August 2017

issue

3

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9 August 2017

page(s)

226-236

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Fifty years later: the significance of the Nuremberg Code

9 August 2017

cites work

1 reference

31 March 2020

Adverse drug reactions

1 reference

Predictability of clinical adverse reactions of drugs by general pharmacology studies

31 March 2020

1 reference

Drug safety tests and subsequent clinical experience

31 March 2020

1 reference

Concordance of the toxicity of pharmaceuticals in humans and in animals

31 March 2020

1 reference

Trends in the development of new medicines by UK-owned pharmaceutical companies (1964-1980).

31 March 2020

1 reference

The evaluation of anticancer drugs in dogs and monkeys for the prediction of qualitative toxicities in man

31 March 2020

1 reference

Predicting anticancer drug effects in man from laboratory animal studies

31 March 2020

1 reference

QT interval prolongation by non-cardiovascular drugs: issues and solutions for novel drug development

31 March 2020

1 reference

QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience

31 March 2020

1 reference

The impact of drug-induced QT interval prolongation on drug discovery and development

31 March 2020

1 reference

The pre-clinical assessment of QT interval prolongation: a comparison of in vitro and in vivo methods

31 March 2020

1 reference

Comparison of canine and human gastrointestinal physiology

31 March 2020

1 reference

Drug-induced hepatotoxicity.

31 March 2020

1 reference

Serum transaminase elevations as indicators of hepatic injury following the administration of drugs

31 March 2020

1 reference

Effect of troglitazone in insulin-treated patients with type II diabetes mellitus. Troglitazone and Exogenous Insulin Study Group.

31 March 2020

1 reference

Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus

31 March 2020

1 reference

The effects of drugs and chemicals upon the structure of the adrenal gland

31 March 2020

1 reference

Toxicological assessment of the hemostatic system, regulatory requirements, and industry practice

31 March 2020

1 reference

Report of validation study of assessment of direct immunotoxicity in the rat. The ICICIS Group Investigators. International Collaborative Immunotoxicity Study

31 March 2020

1 reference

Issues with introducing new immunotoxicology methods into the safety assessment of pharmaceuticals

31 March 2020

1 reference

Immunotoxicology assessment in the pharmaceutical industry

31 March 2020

1 reference

Preclinical safety evaluation of biotechnology-derived pharmaceuticals

31 March 2020

1 reference

Abdominal exploration for gastrointestinal bleeding of obscure origin

31 March 2020

1 reference

Mutagenicity in drug development: interpretation and significance of test results.

31 March 2020

1 reference

Designing safer drugs: (Q)SAR-based identification of mutagens and carcinogens

31 March 2020

1 reference

Are single-dose toxicology studies in animals adequate to support single doses of a new drug in humans?

31 March 2020

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Response to Monro and Mehta proposal for use of single-dose toxicology studies to support single-dose studies of new drugs in humans

31 March 2020

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Early microdose drug studies in human volunteers can minimise animal testing: Proceedings of a workshop organised by Volunteers in Research and Testing

31 March 2020

1 reference

Big physics, small doses: the use of AMS and PET in human microdosing of development drugs

31 March 2020

1 reference

Toxicology rethinks its central belief

31 March 2020

1 reference

What does the clinician want to know from the toxicologist?

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1329

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Dimensions Publication ID

9 August 2017

1023595874

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