Wikidata

(Q21494203)

English

Cyclic GMP-AMP synthase

mammalian protein found in Mus musculus

  • cyclic GMP-AMP synthase
  • mab-21 domain-containing protein 1
  • Mb21d1
  • Mab-21 domain containing 1
  • cGAMP synthase
  • 2'3'-cGAMP synthase
  • Cgas
In more languages

Statements

molecular function
2',3'-cyclic GMP-AMP synthase activity
determination method
IEA
ISO
IMP
IDA
7 references
retrieved
7 November 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
ISO
retrieved
7 November 2018
stated in
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IMP
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IEA
retrieved
7 November 2018
stated in
Mitotic progression following DNA damage enables pattern recognition within micronuclei.
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA
retrieved
7 November 2018
stated in
The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA
retrieved
7 November 2018
stated in
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA
retrieved
7 November 2018
stated in
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA
biological process
cellular response to exogenous dsRNA
determination method
IDA
IEA
IMP
ISO
6 references
retrieved
7 November 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
ISO
retrieved
7 November 2018
stated in
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IMP
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IEA
retrieved
7 November 2018
stated in
The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA
retrieved
7 November 2018
stated in
Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA
retrieved
7 November 2018
stated in
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA
activation of innate immune response
determination method
IDA
IEA
IMP
ISO
ISS
6 references
retrieved
7 November 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
ISS
retrieved
7 November 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
ISO
retrieved
7 November 2018
stated in
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IMP
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IEA
retrieved
7 November 2018
stated in
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA
retrieved
7 November 2018
stated in
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA
positive regulation of type I interferon production
determination method
IDA
IEA
ISO
ISS
6 references
retrieved
7 November 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
ISS
retrieved
7 November 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
ISO
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IEA
retrieved
7 November 2018
stated in
Mitotic progression following DNA damage enables pattern recognition within micronuclei.
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA
retrieved
7 November 2018
stated in
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA
retrieved
7 November 2018
stated in
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
GOA
curator
UniProt
UniProt protein ID
Q8C6L5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5
determination method
IDA

Identifiers

 
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