(Q29871106)

9 May 2017

title

The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity (English)

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9 May 2017

main subject

Cyclic GMP-AMP synthase

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cellular response to exogenous dsRNA

GOA release 2020-03-11

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GOA release 2020-03-11

Cyclic GMP-AMP synthase

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GOA release 2020-03-11

author name string

Arum Lee

1

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9 May 2017

Eun-Byeol Park

2

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9 May 2017

Janghyun Lee

3

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9 May 2017

Byong-Seok Choi

4

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9 May 2017

Suk-Jo Kang

5

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9 May 2017

language of work or name

English

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publication date

18 February 2017

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9 May 2017

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9 May 2017

volume

591

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9 May 2017

issue

6

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9 May 2017

page(s)

954-961

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Innate immune sensing and signaling of cytosolic nucleic acids

9 May 2017

cites work

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https://api.crossref.org/works/10.1002%2F1873-3468.12598

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 January 2018

1 reference

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Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

Structural mechanism of cytosolic DNA sensing by cGAS

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

IFI16 is an innate immune sensor for intracellular DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

A new adaptive grid-size algorithm for the simulation of sedimentation velocity profiles in analytical ultracentrifugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

OASes and STING: adaptive evolution in concert

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12598

21 January 2018

Identifiers

DOI

10.1002/1873-3468.12598

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9 May 2017

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