Wikidata

(Q22676633)

English

Cyclic GMP-AMP synthase

mammalian protein found in Homo sapiens

  • CGAS
  • cGAMP synthase
  • 2'3'-cGAMP synthase
  • cyclic GMP-AMP synthase
  • mab-21 domain-containing protein 1
  • protein MB21D1
  • MB21D1
  • Mab-21 domain containing 1
In more languages

Statements

molecular function
2',3'-cyclic GMP-AMP synthase activity
determination method
IEA
EXP
IDA
8 references
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IEA
retrieved
7 November 2018
stated in
Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
cGAS surveillance of micronuclei links genome instability to innate immunity
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
EXP
biological process
activation of innate immune response
determination method
IDA
IEA
IMP
6 references
retrieved
7 November 2018
stated in
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IMP
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IEA
retrieved
7 November 2018
stated in
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
positive regulation of type I interferon production
determination method
IDA
IEA
TAS
6 references
retrieved
7 November 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
TAS
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IEA
retrieved
7 November 2018
stated in
Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA
retrieved
7 November 2018
stated in
cGAS surveillance of micronuclei links genome instability to innate immunity
GOA
curator
UniProt
UniProt protein ID
Q8N884
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884
determination method
IDA

Identifiers

 
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