(Q21494665)

http://www.ebi.ac.uk/interpro/protein/P22725

Wnt protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein domain specific binding

1 reference

14 February 2019

The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

DNA-binding transcription factor activity

IPI

3 references

chemoattractant activity involved in axon guidance

1 reference

14 February 2019

Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

signaling receptor binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

3 references

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

9 references

14 February 2019

Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Augmented Wnt signaling in a mammalian model of accelerated aging

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

endoplasmic reticulum lumen

IBA

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

3 references

1 reference

14 February 2019

Wnt family proteins are secreted and associated with the cell surface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Wnt family proteins are secreted and associated with the cell surface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

planar cell polarity pathway involved in outflow tract morphogenesis

1 reference

14 February 2019

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

non-canonical Wnt signaling pathway

3 references

10 October 2017

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Wnt5a regulates midbrain dopaminergic axon growth and guidance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

positive regulation of protein phosphorylation

4 references

14 February 2019

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a regulates midbrain dopaminergic axon growth and guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

paraxial mesoderm formation

1 reference

14 February 2019

Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

cellular response to molecule of bacterial origin

1 reference

14 February 2019

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

WNT5A selectively inhibits mouse ventral prostate development

hindgut morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of JNK cascade

1 reference

14 February 2019

Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

response to organic substance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

mesodermal to mesenchymal transition involved in gastrulation

1 reference

14 February 2019

Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

regulation of protein localization

1 reference

14 February 2019

Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth

protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

epithelial cell proliferation involved in mammary gland duct elongation

1 reference

14 February 2019

Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

establishment of epithelial cell apical/basal polarity

1 reference

14 February 2019

Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation

notochord morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of mesenchymal cell proliferation

1 reference

14 February 2019

Wnt5a is essential for intestinal elongation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

mesenchymal-epithelial cell signaling

1 reference

14 February 2019

Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

negative regulation of epithelial cell proliferation

animal organ morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

TAS

1 reference

14 February 2019

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of thymocyte apoptotic process

1 reference

14 February 2019

Noncanonical Wnt signaling promotes apoptosis in thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

cellular response to interferon-gamma

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Wnt5a is essential for intestinal elongation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of non-canonical Wnt signaling pathway

1 reference

14 February 2019

Wnt5a inhibits the proliferation and melanogenesis of melanocytes

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

type B pancreatic cell development

1 reference

14 February 2019

Wnt5 signaling in vertebrate pancreas development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

primitive streak formation

1 reference

14 February 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

cellular response to transforming growth factor beta stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

cellular response to calcium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

dopaminergic neuron differentiation

4 references

14 February 2019

Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Wnt5a functions in planar cell polarity regulation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Wnt5a participates in distal lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

hematopoietic stem cell proliferation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

embryonic digit morphogenesis

1 reference

14 February 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

regulation of branching involved in mammary gland duct morphogenesis

negative regulation of axon extension involved in axon guidance

1 reference

14 February 2019

The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of peptidyl-serine phosphorylation

1 reference

14 February 2019

Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

morphogenesis of an epithelium

1 reference

14 February 2019

Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

chemorepulsion of dopaminergic neuron axon

positive regulation of transcription, DNA-templated

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

negative regulation of prostatic bud formation

1 reference

14 February 2019

WNT5A selectively inhibits mouse ventral prostate development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of GTPase activity

1 reference

14 February 2019

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of endocytosis

1 reference

14 February 2019

Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

cartilage development

1 reference

14 February 2019

planar cell polarity pathway involved in cardiac right atrium morphogenesis

1 reference

14 February 2019

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

embryonic limb morphogenesis

1 reference

14 February 2019

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of cartilage development

Genetic interaction between Lrp6 and Wnt5a during mouse development

neural tube development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

pericardium morphogenesis

1 reference

14 February 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of interleukin-6 production

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

digestive tract morphogenesis

TAS

1 reference

14 February 2019

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

neuron projection morphogenesis

1 reference

14 February 2019

Wnt5a regulates midbrain dopaminergic axon growth and guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

WNT5A selectively inhibits mouse ventral prostate development

male gonad development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Sfrp1 and Sfrp2 are required for normal male sexual development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

lateral sprouting involved in mammary gland duct morphogenesis

1 reference

14 February 2019

Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of epithelial cell proliferation

1 reference

14 February 2019

Wnt5a is essential for intestinal elongation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

urinary bladder development

1 reference

14 February 2019

WNT5A selectively inhibits mouse ventral prostate development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

planar cell polarity pathway involved in ventricular septum morphogenesis

1 reference

14 February 2019

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

establishment of planar polarity

1 reference

14 February 2019

Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

WNT5A signaling affects pituitary gland shape

hypophysis morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

negative regulation of synapse assembly

1 reference

14 February 2019

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

negative regulation of melanin biosynthetic process

1 reference

14 February 2019

Wnt5a inhibits the proliferation and melanogenesis of melanocytes

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

Wnt signaling pathway, calcium modulating pathway

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Noncanonical Wnt signaling promotes apoptosis in thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

epithelial to mesenchymal transition

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

canonical Wnt signaling pathway

6 references

14 February 2019

Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

planar cell polarity pathway involved in pericardium morphogenesis

1 reference

14 February 2019

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of protein binding

1 reference

14 February 2019

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

ameboidal-type cell migration

1 reference

14 February 2019

Wnt5a is essential for intestinal elongation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

planar cell polarity pathway involved in gastrula mediolateral intercalation

1 reference

14 February 2019

Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of protein kinase activity

1 reference

14 February 2019

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of cell-cell adhesion mediated by cadherin

1 reference

14 February 2019

Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

non-canonical Wnt signaling pathway via JNK cascade

1 reference

14 February 2019

Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of cytokine production

1 reference

14 February 2019

Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

activation of GTPase activity

1 reference

14 February 2019

Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

development of primary male sexual characteristics

1 reference

14 February 2019

Sfrp1 and Sfrp2 are required for normal male sexual development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

mammary gland branching involved in thelarche

TAS

1 reference

14 February 2019

Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of interferon-gamma production

1 reference

14 February 2019

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

keratinocyte differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

planar cell polarity pathway involved in neural tube closure

1 reference

14 February 2019

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Wnt5a regulates midbrain dopaminergic axon growth and guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

negative regulation of BMP signaling pathway

1 reference

14 February 2019

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

multicellular organism development

negative regulation of fibroblast growth factor receptor signaling pathway

2 references

1 reference

14 February 2019

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

determination of left/right symmetry

1 reference

14 February 2019

Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of peptidyl-threonine phosphorylation

1 reference

14 February 2019

Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

inner ear morphogenesis

olfactory bulb interneuron development

1 reference

14 February 2019

Wnt5a controls neurite development in olfactory bulb interneurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of neuron projection development

1 reference

14 February 2019

Wnt5a controls neurite development in olfactory bulb interneurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of meiotic nuclear division

1 reference

14 February 2019

Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

Wnt5a inhibits the proliferation and melanogenesis of melanocytes

melanocyte proliferation

1 reference

14 February 2019

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

cellular response to lipopolysaccharide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

anterior/posterior axis specification, embryo

1 reference

14 February 2019

A member of the Frizzled protein family mediating axis induction by Wnt-5A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

chemoattraction of serotonergic neuron axon

1 reference

14 February 2019

Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

1 reference

14 February 2019

Wnt5a is essential for intestinal elongation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

Wnt signaling pathway

7 references

10 October 2017

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

Wnt signaling pathway, planar cell polarity pathway

7 references

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Wnt5a functions in planar cell polarity regulation in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Wnt5a functions in planar cell polarity regulation in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

negative regulation of canonical Wnt signaling pathway

10 references

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Noncanonical Wnt signaling promotes apoptosis in thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Wnt5a inhibits the proliferation and melanogenesis of melanocytes

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

10 October 2017

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

negative regulation of cell proliferation in midbrain

1 reference

14 February 2019

Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

midbrain dopaminergic neuron differentiation

4 references

14 February 2019

Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

planar cell polarity pathway involved in axon guidance

Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

1 reference

14 February 2019

Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of timing of anagen

1 reference

14 February 2019

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of canonical Wnt signaling pathway

1 reference

10 October 2017

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22725&geneProductId=UniProtKB:P22725

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of gene expression

1 reference

14 February 2019

WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

Wnt signaling pathway

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of cell-cell adhesion

IBA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

ISO

neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

non-canonical Wnt signaling pathway

IBA

3 references

14 February 2019

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a regulates midbrain dopaminergic axon growth and guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

14 February 2019

WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

Wnt signaling pathway, planar cell polarity pathway

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a functions in planar cell polarity regulation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a functions in planar cell polarity regulation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

negative regulation of canonical Wnt signaling pathway

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Noncanonical Wnt signaling promotes apoptosis in thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnt5a inhibits the proliferation and melanogenesis of melanocytes

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

14 February 2019

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

positive regulation of neuron death

1 reference

14 February 2019

WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22725

Wnt protein, conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0