(Q21494863)

adenomatous polyposis coli protein

1 reference

Adenomatous polyposis coli

1 reference

APC, N-terminal coiled-coil domain superfamily

1 reference

Armadillo-type fold

1 reference

Adenomatous polyposis coli, N-terminal dimerisation domain, protein family

1 reference

Adenomatous polyposis coli protein basic domain, protein family

1 reference

EB-1 binding domain, protein family

1 reference

armadillo domain proteins

1 reference

SAMP, protein family

1 reference

Armadillo domain, protein family

1 reference

Adenomatous polyposis coli protein repeat family

1 reference

Adenomatous polyposis coli protein, 15 residue repeat, protein family

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

protein kinase regulator activity

English

molecular function

2 references

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

4 references

14 February 2019

Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

3 references

microtubule plus-end binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

ubiquitin protein ligase binding

IDA

1 reference

14 February 2019

Putative tumor suppressor EDD interacts with and up-regulates APC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

gamma-catenin binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

protein-containing complex binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

bicellular tight junction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

2 references

2 references

cell projection membrane

1 reference

14 February 2019

Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

3 references

lateral plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

3 references

1 reference

14 February 2019

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

Scrib-APC-beta-catenin complex

IDA

1 reference

14 February 2019

Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

cytoplasmic microtubule

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

perinuclear region of cytoplasm

1 reference

14 February 2019

Putative tumor suppressor EDD interacts with and up-regulates APC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

neuron projection terminus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin

cytoplasmic microtubule

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

beta-catenin destruction complex

3 references

pattern specification process

1 reference

24 April 2018

Apc tumor suppressor gene is the "zonation-keeper" of mouse liver

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

T cell differentiation in thymus

1 reference

14 February 2019

Loss of adenomatous polyposis coli gene function disrupts thymic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

muscle cell cellular homeostasis

1 reference

14 February 2019

Interleukin-6 and cachexia in ApcMin/+ mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

negative regulation of Wnt signaling pathway

9 references

14 February 2019

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Apc tumor suppressor gene is the "zonation-keeper" of mouse liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Disruption of early proximodistal patterning and AVE formation in Apc mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Inactivation of Apc in the mouse prostate causes prostate carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Deficiency of Mbd2 attenuates Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

negative regulation of odontogenesis

1 reference

14 February 2019

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

cellular response to DNA damage stimulus

3 references

stem cell population maintenance

1 reference

14 February 2019

A critical role for Apc in hematopoietic stem and progenitor cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

regulation of osteoblast differentiation

1 reference

14 February 2019

Essential role of beta-catenin in postnatal bone acquisition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

negative regulation of epithelial cell proliferation

4 references

24 April 2018

APC mutation and the crypt cycle in murine and human intestine

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

positive regulation of microtubule polymerization

1 reference

14 February 2019

Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

negative regulation of canonical Wnt signaling pathway

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

negative regulation of cell population proliferation

68 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Inactivation of both APC alleles in human and mouse tumors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

APC-dependent suppression of colon carcinogenesis by PPARgamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

In utero and neonatal sensitivity of ApcMin/+ mice to radiation-induced intestinal neoplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

T cell status influences colon tumor occurrence in min mice fed short chain fructo-oligosaccharides as a diet supplement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

APC inhibits ERK pathway activation and cellular proliferation induced by RAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Myc deletion rescues Apc deficiency in the small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Localized gene action controlling intestinal neoplasia in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Gastro-intestinal tumorigenesis in Smad4 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Deficiency of Mbd2 attenuates Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Meta-analysis of gene expression in mouse preimplantation embryo development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Alpha-catenin is essential in intestinal adenoma formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Interleukin-6 and cachexia in ApcMin/+ mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Functional PKC in vivo analysis using deficient mouse models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

The H19 locus acts in vivo as a tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

regulation of nitrogen compound metabolic process

1 reference

14 February 2019

Apc tumor suppressor gene is the "zonation-keeper" of mouse liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

regulation of osteoclast differentiation

1 reference

14 February 2019

Essential role of beta-catenin in postnatal bone acquisition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

cytoplasmic microtubule organization

1 reference

14 February 2019

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

hair follicle development

1 reference

14 February 2019

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

proximal/distal pattern formation

1 reference

14 February 2019

Disruption of early proximodistal patterning and AVE formation in Apc mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

canonical Wnt signaling pathway involved in positive regulation of apoptotic process

1 reference

14 February 2019

Myc deletion rescues Apc deficiency in the small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human

chromosome organization

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

mitotic spindle assembly checkpoint signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

retina development in camera-type eye

1 reference

14 February 2019

Ultrastructural and ERG findings in mice with adenomatous polyposis coli gene disruption

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

canonical Wnt signaling pathway

1 reference

14 February 2019

Disruption of early proximodistal patterning and AVE formation in Apc mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

regulation of epithelial cell differentiation

1 reference

14 February 2019

APC in the regulation of intestinal crypt fission

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

dorsal/ventral pattern formation

1 reference

14 February 2019

Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

14 February 2019

Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

3 references

14 February 2019

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

somatic stem cell population maintenance

Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo

Wnt signaling pathway

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

IDA

1 reference

14 February 2019

Myc deletion rescues Apc deficiency in the small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients

regulation of cell cycle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

positive regulation of epithelial cell differentiation

1 reference

24 April 2018

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

negative regulation of microtubule depolymerization

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

positive regulation of pseudopodium assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

negative regulation of epithelial cell proliferation involved in prostate gland development

1 reference

14 February 2019

Inactivation of Apc in the mouse prostate causes prostate carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

positive regulation of apoptotic process

3 references

14 February 2019

Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Loss of adenomatous polyposis coli gene function disrupts thymic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

regulation of cell differentiation

1 reference

24 April 2018

Myc deletion rescues Apc deficiency in the small intestine

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315

positive regulation of cell division

1 reference

14 February 2019

Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindac

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

anterior/posterior pattern specification

1 reference

14 February 2019

Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

positive regulation of cell adhesion

1 reference

14 February 2019

Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

positive regulation of cell death

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

protein homooligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

establishment or maintenance of cell polarity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

neuron projection development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

negative regulation of cardiac muscle cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

regulation of glutamate metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

cell fate specification

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

negative regulation of microtubule depolymerization

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

positive regulation of epithelial cell differentiation

1 reference

14 February 2019

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

negative regulation of molecular function

1 reference

14 February 2019

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

positive regulation of protein catabolic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

APC inhibits ERK pathway activation and cellular proliferation induced by RAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

negative regulation of epithelial cell proliferation

5 references

14 February 2019

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

APC mutation and the crypt cycle in murine and human intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

negative regulation of canonical Wnt signaling pathway

6 references

14 February 2019

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

positive regulation of cold-induced thermogenesis

1 reference

14 February 2019

Extensive metabolic disorders are present in APC(min) tumorigenesis mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315

1 reference

Adenomatous polyposis coli protein repeat

1 reference

Adenomatous polyposis coli protein, 15 residue repeat

1 reference

EB-1 binding

1 reference

Adenomatous polyposis coli protein basic domain

1 reference

Armadillo

1 reference

Adenomatous polyposis coli, N-terminal dimerisation domain

1 reference

Identifiers

1 reference

9 August 2016

1 reference

9 August 2016