(Q28510491)

English

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human

scientific journal article

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scholarly article

2 references

25 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17200209%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human (English)

2 references

25 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17200209%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

Adenomatous polyposis coli protein

1 reference

GOA release 2020-03-11

Transformation related protein 53

1 reference

GOA release 2020-03-11

2

1 reference

Europe PubMed Central

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23 December 2019

3

1 reference

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23 December 2019

7

1 reference

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23 December 2019

author name string

Paola Alberici

1

2 references

25 January 2017

Europe PubMed Central

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23 December 2019

Mieke Bevelander

4

2 references

25 January 2017

Europe PubMed Central

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23 December 2019

Lia Molenaar

5

2 references

25 January 2017

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23 December 2019

Jos Jonkers

6

2 references

25 January 2017

Europe PubMed Central

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23 December 2019

language of work or name

0 references

publication date

1 January 2007

2 references

25 January 2017

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23 December 2019

The American Journal of Pathology

2 references

25 January 2017

Europe PubMed Central

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23 December 2019

170

2 references

25 January 2017

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23 December 2019

1

2 references

25 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17200209%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

377-387

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17200209%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

Systemic tumor suppression by the proapoptotic gene bik

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

19 March 2017

Human APC2 localization and allelic imbalance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

19 March 2017

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

19 March 2017

Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

19 March 2017

Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

19 March 2017

Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

19 March 2017

Mutations of mitotic checkpoint genes in human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

19 March 2017

Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

19 March 2017

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

19 March 2017

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

19 March 2017

A genetic model for colorectal tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

19 March 2017

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

7 April 2017

Genetic instability in colorectal cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

7 April 2017

Tumor spectrum analysis in p53-mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

7 April 2017

The role of the APC tumor suppressor in chromosomal instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Expression and genomic profiling of colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Chromosomal instability in MYH- and APC-mutant adenomatous polyps

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Apoptotic signaling pathways: caspases and stress-activated protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Deletion at chromosome band 20p12.1 in colorectal cancer revealed by high resolution array comparative genomic hybridization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Expression of ST13 in colorectal cancer and adjacent normal tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

The tuberous sclerosis complex genes in tumor development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

MAD2 dependent mitotic checkpoint defects in tumorigenesis and tumor cell death: a double edged sword.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

hCDC4 and genetic instability in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Genomic instability and colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Inactivation of hCDC4 can cause chromosomal instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Pathology of mouse models of intestinal cancer: consensus report and recommendations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Intestinal adenomas can develop with a stable karyotype and stable microsatellites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

APC, signal transduction and genetic instability in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Mammalian G1- and S-phase checkpoints in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Disease model: familial adenomatous polyposis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

The Ras pathway and spindle assembly collide?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Mechanisms underlying losses of heterozygosity in human colorectal cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

29 September 2017

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

2 June 2018

Common patterns of genetic evolution in human solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

2 June 2018

Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

2 June 2018

Transfection of human mutated K-ras in mouse NIH-3T3 cells is associated with increased cloning efficiency and DNA aneuploidization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

2 June 2018

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

2 June 2018

Tetraploidy and tumor development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

27 November 2018

Genomic heterogeneity and instability in colorectal cancer: spectral karyotyping, glutathione transferase-Ml and ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

27 November 2018

p300 gene alterations in intestinal and diffuse types of gastric carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

27 November 2018

High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

27 November 2018

Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

27 November 2018

Analysis of genetic alterations, classified according to their DNA ploidy pattern, in the progression of colorectal adenomas and early colorectal carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

27 November 2018

A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762685

27 November 2018

Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Array-CGH analysis of microsatellite-stable, near-diploid bowel cancers and comparison with other types of colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smad4 haploinsufficiency in mouse models for intestinal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of chromosome 1p and loss of expression of alkaline phosphatase indicate progression of meningiomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the APC tumour suppressor gene cause chromosomal instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation analysis of EP300 in colon, breast and ovarian carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K-ras mutations in putative preneoplastic lesions in human colon

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of Apc+ in intestinal adenomas from Min mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K-ras-2 G-C and G-T transversions correlate with DNA aneuploidy in colorectal adenomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rectal cancer following colectomy and ileorectal anastomosis for familial adenomatous polyposis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17200209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2353/AJPATH.2007.060853

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17200209%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17200209%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

2 references

25 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17200209%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

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