(Q34430311)

2 August 2017

title

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC. (English)

1 reference

2 August 2017

12

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2 August 2017

13

Tomlinson IP

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2 August 2017

Sieber OM

1

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2 August 2017

Heinimann K

2

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2 August 2017

Gorman P

3

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2 August 2017

Lamlum H

4

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2 August 2017

Crabtree M

5

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2 August 2017

Simpson CA

6

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2 August 2017

Davies D

7

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2 August 2017

Neale K

8

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2 August 2017

Hodgson SV

9

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2 August 2017

Roylance RR

10

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2 August 2017

Phillips RK

11

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2 August 2017

language of work or name

English

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publication date

16 December 2002

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Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

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2 August 2017

volume

99

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2 August 2017

issue

26

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2 August 2017

page(s)

16910-16915

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Intestinal adenomas can develop with a stable karyotype and stable microsatellites

2 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

6 July 2018

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6 July 2018

1 reference

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Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Asef, a link between the tumor suppressor APC and G-protein signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

APC mutations are sufficient for the growth of early colorectal adenomas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Beta-catenin mutations in cell lines established from human colorectal cancers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

DNA aneuploidy in colorectal adenomas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Flow cytometry and colorectal neoplasia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.012679099

Flow cytometric analysis of the DNA content in colorectal adenomas with focal cancers.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.012679099

Comparative genomic hybridization of breast tumors stratified by histological grade reveals new insights into the biological progression of breast cancer.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139243

Degenerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primer

27 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.012679099

DNA flow cytometry of endoscopically examined colorectal adenomas and adenocarcinomas

21 January 2018

1 reference

12 December 2020

Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis

1 reference

12 December 2020

Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP)

1 reference

12 December 2020

The chromosome make-up of mouse embryonic stem cells is predictive of somatic and germ cell chimaerism

1 reference

12 December 2020

Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas

1 reference

12 December 2020

Mutations in the APC tumour suppressor gene cause chromosomal instability

1 reference

12 December 2020

Characterization of human adenomatous polyps of the colorectal bowel by means of DNA distribution patterns

1 reference

12 December 2020

Flow cytometric detection of aneuploidy in colorectal adenomas

1 reference

12 December 2020

Characteristics of colorectal epithelia and adenomas as revealed by DNA cytofluorometry

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.012679099

1 reference

2 August 2017

0 references

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2 August 2017

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