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The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.
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stated in
Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
review article
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Europe PubMed Central
title
The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
main subject
polyposis
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author
Oliver Sieber
series ordinal
1
1 reference
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Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
Ian Tomlinson
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2
object named as
Tomlinson IP
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
author name string
Lamlum H
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3
1 reference
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Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
publication date
1 December 2000
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Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
published in
Trends in Molecular Medicine
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
volume
6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
issue
12
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
page(s)
462-469
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
cites work
Identification and characterization of the familial adenomatous polyposis coli gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
APC expression in normal human tissues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunochemical identification of novel high-molecular-weight protein isoforms of the adenomatous polyposis coli (APC) gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel coding exon of the human adenomatous polyposis coli gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple APC messenger RNA isoforms encoding exon 15 short open reading frames are expressed in the context of a novel exon 10A‐derived sequence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dimer formation by an N-terminal coiled coil in the APC protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Asef, a link between the tumor suppressor APC and G-protein signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of the APC tumor suppressor protein with catenins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of the APC gene product with beta-catenin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The APC tumour suppressor has a nuclear export function.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The APC protein binds to A/T rich DNA sequences
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The APC gene product in normal and tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wnt/beta-catenin signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cadherin-catenin complex: Protein interactions and their implications for cadherin function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
beta-catenin is a target for the ubiquitin-proteasome pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of c-MYC as a target of the APC pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-cell contact and specific cytokines inhibit apoptosis of colonic epithelial cells: growth factors protect against c-myc-independent apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis and APC in colorectal tumorigenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation rate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
APC gene: database of germline and somatic mutations in human tumors and cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations of the APC (adenomatous polyposis coli) gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypertrophy of the retinal pigment epithelium associated with Gardner's syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Occurrence of desmoid tumours in familial adenomatous polyposis and results of treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Familial adenomatous polyposis: desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genotype-phenotype correlations in attenuated adenomatous polyposis coli
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two cases of 5q deletions in patients with familial adenomatous polyposis: possible link with Caroli's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deletions of the entire APC gene are associated with sessile colonic adenomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A family with attenuated familial adenomatous polyposis due to a mutation in the alternatively spliced region of APC exon 9
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prevalence of the APC E1317Q variant in colorectal cancer patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lessons from hereditary colorectal cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
APC mutations are sufficient for the growth of early colorectal adenomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the beta-catenin gene by interstitial deletions involving exon 3 as an early event in colorectal tumorigenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic mutations of β-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
APC in the regulation of intestinal crypt fission
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Familial adenomatous polyposis: a submicroscopic deletion at the APC locus in a family with mentally normal patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Localization of the gene for familial adenomatous polyposis on chromosome 5.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gardner syndrome in a man with an interstitial deletion of 5q.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1357-4310(00)01828-1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
PubMed publication ID
11099951
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11099951
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
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