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(Q21495511)
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DAN domain family member 5, BMP antagonist
mammalian protein found in Mus musculus
Cerl-2
cerberus-like protein 2
Dand5
DAN domain family, member 5
dante
DAN domain family member 5
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q76LW6
subclass of
protein
1 reference
stated in
UniProt
retrieved
19 January 2017
UniProt protein ID
Q76LW6
part of
Cystine-knot cytokine
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q76LW6
Cerberus
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q76LW6
DAN domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Cystine knot, C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q76LW6
encoded by
Dand5
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q76LW6
molecular function
protein binding
determination method
IPI
1 reference
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IPI
morphogen activity
determination method
IMP
1 reference
retrieved
24 April 2018
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q76LW6&geneProductId=UniProtKB:Q76LW6
determination method
IMP
morphogen activity
determination method
IBA
IMP
2 references
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IMP
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IBA
cell component
extracellular region
determination method
NAS
IEA
2 references
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
NAS
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q76LW6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IEA
extracellular space
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IBA
biological process
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
determination method
NAS
1 reference
retrieved
14 February 2019
stated in
Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
NAS
negative regulation of nodal signaling pathway
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IDA
sequestering of nodal from receptor via nodal binding
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IDA
determination of left/right symmetry
determination method
IGI
IMP
2 references
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IMP
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IGI
determination of heart left/right asymmetry
determination method
IMP
1 reference
retrieved
24 April 2018
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q76LW6&geneProductId=UniProtKB:Q76LW6
determination method
IMP
negative regulation of transforming growth factor beta receptor signaling pathway
determination method
IGI
1 reference
retrieved
14 February 2019
stated in
ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IGI
atrial septum development
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IMP
negative regulation of nodal signaling pathway involved in determination of left/right asymmetry
determination method
ISS
1 reference
retrieved
14 February 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
ISS
ventricular septum development
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IMP
determination of left/right asymmetry in lateral mesoderm
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IMP
regulation of transforming growth factor beta receptor signaling pathway
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
A mouse cerberus/Dan-related gene family
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IDA
negative regulation of BMP signaling pathway
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IDA
signal transduction involved in regulation of gene expression
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IBA
sequestering of BMP in extracellular matrix
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IBA
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IBA
regulation of signaling receptor activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IEA
determination of heart left/right asymmetry
determination method
IBA
IMP
2 references
retrieved
14 February 2019
stated in
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IMP
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LW6
determination method
IBA
has part(s)
Cystine knot, C-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q76LW6
DAN
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q76LW6
Identifiers
RefSeq protein ID
NP_957679
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
23863
UniProt protein ID
Q76LW6
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q76LW6
Ensembl protein ID
ENSMUSP00000070057
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000070057
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