(Q21496233)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63044

synaptosomal vesicle fusion pore

1 reference

Transporter Classification Database ID

1.F.1.1.4

hierarchical database ID heuristic

2 October 2019

based on heuristic

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Synaptobrevin

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

SNAP receptor activity

1 reference

9 August 2016

1 reference

9 August 2016

21 references

9 August 2016

9 May 2019

Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Role of vesicle-associated membrane protein 2 in exocytosis of glucagon-like peptide-1 from the murine intestinal L cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Identification of a novel Bves function: regulation of vesicular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Munc18c depletion selectively impairs the sustained phase of insulin release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Interaction assays in yeast and cultured cells confirm known and identify novel partners of the synaptic vesicle protein synaptophysin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

CSPα knockout causes neurodegeneration by impairing SNAP-25 function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

4 references

9 August 2016

9 May 2019

Complexins: cytosolic proteins that regulate SNAP receptor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

calcium-dependent protein binding

1 reference

9 August 2016

identical protein binding

1 reference

9 August 2016

transmembrane transporter binding

1 reference

9 August 2016

protein C-terminus binding

1 reference

9 August 2016

protein-containing complex binding

1 reference

9 August 2016

1 reference

9 August 2016

Complexins: cytosolic proteins that regulate SNAP receptor function

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Conformational switch of syntaxin-1 controls synaptic vesicle fusion

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

14 February 2019

Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

calcium-dependent protein binding

IBA

3 references

9 May 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

secretory granule membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Expression, Localization, and Biochemical Characterization of Nicotinamide Mononucleotide Adenylyltransferase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Interaction assays in yeast and cultured cells confirm known and identify novel partners of the synaptic vesicle protein synaptophysin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

synaptic vesicle membrane

4 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

16 September 2017

Molecular determinants of synapsin targeting to presynaptic terminals

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

16 September 2017

Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules

zymogen granule membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

1 reference

9 May 2019

Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

perinuclear region of cytoplasm

1 reference

9 May 2019

Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

synaptobrevin 2-SNAP-25-syntaxin-1a complex

3 references

9 May 2019

Complexins: cytosolic proteins that regulate SNAP receptor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

1 reference

9 May 2019

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

cytoplasmic vesicle membrane

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex

TAS

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

neuron projection terminus

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

intracellular organelle

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

4 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

16 September 2017

AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

16 September 2017

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

extracellular exosome

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

intracellular membrane-bounded organelle

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

integral component of synaptic vesicle membrane

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63044&geneProductId=UniProtKB:P63044

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

voltage-gated potassium channel complex

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Role of vesicle-associated membrane protein 2 in exocytosis of glucagon-like peptide-1 from the murine intestinal L cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

synaptic vesicle membrane

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

9 May 2019

Molecular determinants of synapsin targeting to presynaptic terminals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

1 reference

9 May 2019

Role of vesicle-associated membrane protein 2 in exocytosis of glucagon-like peptide-1 from the murine intestinal L cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

synaptic vesicle exocytosis

biological process

1 reference

9 August 2016

1 reference

9 August 2016

calcium-ion regulated exocytosis

IMP

membrane organization

1 reference

9 August 2016

regulation of delayed rectifier potassium channel activity

1 reference

9 August 2016

regulation of exocytosis

1 reference

9 August 2016

eosinophil degranulation

2 references

9 August 2016

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

vesicle-mediated transport

ISO

1 reference

9 August 2016

1 reference

9 August 2016

regulation of insulin secretion

1 reference

9 August 2016

1 reference

9 August 2016

synaptic vesicle exocytosis

regulation of exocytosis

exocytic insertion of neurotransmitter receptor to postsynaptic membrane

regulation of delayed rectifier potassium channel activity

1 reference

9 May 2019

Role of vesicle-associated membrane protein 2 in exocytosis of glucagon-like peptide-1 from the murine intestinal L cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

1 reference

9 May 2019

Role of vesicle-associated membrane protein 2 in exocytosis of glucagon-like peptide-1 from the murine intestinal L cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63044

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63044

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

Transporter Classification Database ID

1.F.1.1.4

2 references

Transporter Classification database

13 March 2020

Transporter Classification database