(Q21497080)

Apoptosis regulator BAK

1 reference

membrane proteins

1 reference

inferred from GOA cell component → membrane

Apoptosis regulator, Bcl-2, BH3 motif, conserved site, protein family

1 reference

inferred from protein domain or family

Apoptosis regulator, Bcl-2, BH1 motif, conserved site, protein family

1 reference

inferred from protein domain or family

Apoptosis regulator, Bcl-2, BH2 motif, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

9 references

14 February 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

VDAC2 inhibits BAK activation and mitochondrial apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Structural plasticity underpins promiscuous binding of the prosurvival protein A1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

BH3 domains other than Bim and Bid can directly activate Bax/Bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

heat shock protein binding

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

protein heterodimerization activity

3 references

protein homodimerization activity

3 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

integral component of membrane

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

integral component of mitochondrial outer membrane

1 reference

14 February 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

intracellular anatomical structure

IDA

1 reference

10 October 2017

Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

IDA

endoplasmic reticulum

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

8 references

10 October 2017

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

Role of Bax and Bak in mitochondrial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

8 references

14 February 2019

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Role of Bax and Bak in mitochondrial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

mitochondrial outer membrane

HDA

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

3 references

mitochondrial membranes

1 reference

14 February 2019

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

IDA

biological process

leukocyte homeostasis

regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

establishment or maintenance of transmembrane electrochemical gradient

1 reference

14 February 2019

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

positive regulation of calcium ion transport into cytosol

1 reference

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

B cell apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

homeostasis of number of cells

1 reference

14 February 2019

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

response to organic cyclic compound

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

1 reference

14 February 2019

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

cellular response to UV

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

myeloid cell homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

post-embryonic camera-type eye morphogenesis

1 reference

14 February 2019

Persistent fetal ocular vasculature in mice deficient in bax and bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

thymocyte apoptotic process

1 reference

14 February 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

regulation of cell cycle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

regulation of mitochondrial membrane potential

cellular response to mechanical stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

Persistent fetal ocular vasculature in mice deficient in bax and bak

blood vessel remodeling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

1 reference

14 February 2019

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

regulation of mitochondrial membrane permeability

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

fibroblast apoptotic process

1 reference

14 February 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

apoptotic process involved in blood vessel morphogenesis

1 reference

14 February 2019

Persistent fetal ocular vasculature in mice deficient in bax and bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

1 reference

14 February 2019

Bax and Bak independently promote cytochrome C release from mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

animal organ regeneration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

intrinsic apoptotic signaling pathway in response to DNA damage

3 references

10 October 2017

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

negative regulation of peptidyl-serine phosphorylation

1 reference

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

positive regulation of apoptotic process

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of endoplasmic reticulum calcium ion concentration

1 reference

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

cell population proliferation

1 reference

14 February 2019

Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

activation of cysteine-type endopeptidase activity involved in apoptotic process

3 references

14 February 2019

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Proapoptotic BAX and BAK control multiple initiator caspases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

response to gamma radiation

1 reference

14 February 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

response to hydrogen peroxide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

endocrine pancreas development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

release of cytochrome c from mitochondria

4 references

14 February 2019

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

B cell negative selection

1 reference

14 February 2019

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

response to mycotoxin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

negative regulation of cell population proliferation

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

positive regulation of release of cytochrome c from mitochondria

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

negative regulation of gene expression

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

intrinsic apoptotic signaling pathway in response to DNA damage

4 references

14 February 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

extrinsic apoptotic signaling pathway in absence of ligand

3 references

14 February 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

Apoptosis regulator, Bcl-2, BH3 motif, conserved site

IBA

has part(s)

1 reference

Apoptosis regulator, Bcl-2, BH1 motif, conserved site

1 reference

Apoptosis regulator, Bcl-2, BH2 motif, conserved site

1 reference