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Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
scientific journal article
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scholarly article
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
title
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
(English)
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
main subject
endoplasmic reticulum
0 references
apoptotic process
0 references
Caspase 12
1 reference
stated in
GOA release 2020-03-11
BCL2-associated X protein
1 reference
stated in
GOA release 2020-03-11
BCL2-antagonist/killer 1
1 reference
stated in
GOA release 2020-03-11
Caspase 9
1 reference
stated in
GOA release 2020-03-11
Caspase 3
1 reference
stated in
GOA release 2020-03-11
author
Craig B. Thompson
series ordinal
7
object named as
Craig B. Thompson
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
author name string
Wei-Xing Zong
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
Chi Li
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
Georgia Hatzivassiliou
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
Tullia Lindsten
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
Qian-Chun Yu
series ordinal
5
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
Junying Yuan
series ordinal
6
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
language of work or name
English
0 references
publication date
7 July 2003
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
published in
Journal of Cell Biology
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
volume
162
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
issue
1
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
page(s)
59–69
1 reference
stated in
PubMed
PubMed ID
12847083
retrieved
31 January 2017
cites work
BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
The expanding role of mitochondria in apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
PUMA, a novel proapoptotic gene, is induced by p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
PUMA induces the rapid apoptosis of colorectal cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Induction of apoptosis by the Bcl-2 homologue Bak
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
17 March 2017
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
7 April 2017
Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
7 April 2017
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
7 April 2017
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Organelle-specific initiation of cell death pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Cisplatin induces the proapoptotic conformation of Bak in a deltaMEKK1-dependent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
29 September 2017
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
3 June 2018
Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
3 June 2018
The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
3 June 2018
Synergistic movements of Ca(2+) and Bax in cells undergoing apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
27 November 2018
Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
27 November 2018
Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172724
retrieved
27 November 2018
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12847083
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12847083
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12847083
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12847083
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12847083
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1083/JCB.200302084
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1339486
OpenCitations bibliographic resource ID
1339486
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1339486
PMCID
2172724
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1339486
PubMed ID
12847083
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1339486
ResearchGate publication ID
10673781
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