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Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
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scholarly article
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PubMed
PubMed ID
15967824
retrieved
31 January 2017
title
Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
(English)
1 reference
stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
main subject
apoptotic process
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hemopoiesis
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apoptotic process involved in embryonic digit morphogenesis
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1902263
BCL2-associated X protein
1 reference
stated in
GOA release 2020-03-11
BCL2-antagonist/killer 1
1 reference
stated in
GOA release 2020-03-11
BCL2-like 11 (apoptosis facilitator)
1 reference
stated in
GOA release 2020-03-11
thymocyte
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author
Jack Hutcheson
object named as
Jack Hutcheson
series ordinal
1
0 references
Philippe Bouillet
object named as
Philippe Bouillet
series ordinal
5
0 references
Andreas Strasser
object named as
Andreas Strasser
series ordinal
6
0 references
author name string
John C. Scatizzi
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
Emily Bickel
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
Nathaniel J. Brown
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
Harris Perlman
series ordinal
7
1 reference
stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
language of work or name
English
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publication date
20 June 2005
1 reference
stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
published in
Journal of Experimental Medicine
1 reference
stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
volume
201
1 reference
stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
page(s)
1949–1960
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stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
issue
12
1 reference
stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
cites work
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
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BAD is a pro-survival factor prior to activation of its pro-apoptotic function
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17 March 2017
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17 March 2017
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
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Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
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17 March 2017
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
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Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis
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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
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Bcl-2 and Bax function independently to regulate cell death
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17 March 2017
Bax-deficient mice with lymphoid hyperplasia and male germ cell death
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17 March 2017
The pathophysiology of mitochondrial cell death
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Mitochondria and apoptosis
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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis
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PubMed Central
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7 April 2017
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
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PubMed Central
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7 April 2017
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis
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PubMed Central
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7 April 2017
The Bcl-2 protein family: arbiters of cell survival
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PubMed Central
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Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
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29 September 2017
T-lymphocyte death during shutdown of an immune response
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29 September 2017
Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
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29 September 2017
Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death
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PubMed Central
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Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.
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PubMed Central
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29 September 2017
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
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PubMed Central
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29 September 2017
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29 September 2017
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells
1 reference
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PubMed Central
reference URL
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29 September 2017
Apoptosis in the development and maintenance of the immune system
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PubMed Central
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29 September 2017
Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo.
1 reference
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PubMed Central
reference URL
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29 September 2017
Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim
1 reference
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PubMed Central
reference URL
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29 September 2017
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.
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PubMed Central
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29 September 2017
Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins
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PubMed Central
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29 September 2017
Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death
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PubMed Central
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29 September 2017
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027
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29 September 2017
The 'harmless' release of cytochrome c.
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PubMed Central
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29 September 2017
The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability
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PubMed Central
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29 September 2017
BH3-Only proteins-essential initiators of apoptotic cell death
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PubMed Central
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29 September 2017
Apoptosis signaling
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PubMed Central
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29 September 2017
The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells
1 reference
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PubMed Central
reference URL
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29 September 2017
Mcl-1 deficiency results in peri-implantation embryonic lethality
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PubMed Central
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29 September 2017
Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival
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PubMed Central
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29 September 2017
Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins
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29 September 2017
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
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29 September 2017
Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.
1 reference
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PubMed Central
reference URL
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29 September 2017
The proto-oncogene Bcl-2 and its role in regulating apoptosis
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PubMed Central
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3 June 2018
Bcl-2 and the ICE family of apoptotic regulators: making a connection.
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3 June 2018
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.
1 reference
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Crossref
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https://api.crossref.org/works/10.1084%2FJEM.20041484
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21 January 2018
c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.
1 reference
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Crossref
reference URL
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21 January 2018
BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development
1 reference
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Crossref
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21 January 2018
Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
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PubMed Central
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27 November 2018
Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family.
1 reference
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PubMed Central
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27 November 2018
Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15967824
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Bcl-2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15967824
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15967824
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1084/JEM.20041484
1 reference
stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
PMCID
2212027
0 references
PubMed ID
15967824
1 reference
stated in
PubMed
PubMed ID
15967824
retrieved
31 January 2017
ResearchGate publication ID
7775261
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