(Q35116684)

6 August 2017

1 reference

title

Apoptosis in the development and maintenance of the immune system (English)

1 reference

https://api.crossref.org/works/10.1038/NI0503-410

6 August 2017

1 reference

1 reference

28 December 2023

2

Stanley J Korsmeyer

1 reference

6 August 2017

Joseph T. Opferman

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719730

28 December 2023

language of work or name

English

0 references

publication date

1 May 2003

1 reference

full work available at URL

6 August 2017

http://www.nature.com/articles/ni0503-410.pdf

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/NI0503-410

http://www.nature.com/articles/ni0503-410

28 December 2023

1 reference

https://api.crossref.org/works/10.1038/NI0503-410

28 December 2023

1 reference

6 August 2017

volume

4

1 reference

6 August 2017

issue

5

1 reference

6 August 2017

page(s)

410-415

1 reference

Cell Death in Development

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Apoptosis and T-cell repertoire selection in the thymus

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Positive selection of thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

A differential-avidity model for T-cell selection

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

The role of cytokine receptor signaling in lymphocyte development

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

A profound deficiency in thymic progenitor cells in mice lacking Jak3.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Defective lymphoid development in mice lacking Jak3

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

What keeps a resting T cell alive?

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Immunological memory and protective immunity: understanding their relation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

CTLA4 mediates antigen-specific apoptosis of human T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Apoptosis by death factor

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Rsk1 mediates a MEK-MAP kinase cell survival signal

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Proapoptotic BID is required for myeloid homeostasis and tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

BCL-XL-regulated apoptosis in T cell development.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor-deficient mice but can enhance survival of mature B cells.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Mouse models of cell death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-410

7 January 2021

Identifiers

DOI

10.1038/NI0503-410

1 reference

6 August 2017

1 reference