Wikidata

(Q21498733)

English

Protein kinase, AMP-activated, alpha 2 catalytic subunit

mammalian protein found in Mus musculus

  • HMGCR kinase
  • ACACA kinase
  • acetyl-CoA carboxylase kinase
  • 5'-AMP-activated protein kinase catalytic subunit alpha-2
  • hydroxymethylglutaryl-CoA reductase kinase
  • Prkaa2
  • AMP-activated protein kinase alpha-2 variant B
  • 2.7.11.31
  • AMPK subunit alpha-2
  • 2.7.11.27
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No label defined

No description defined

Statements

molecular function
AMP-activated protein kinase activity
determination method or standard
IEA
IDA
TAS
IMP
ISO
8 references
retrieved
27 February 2018
stated in
Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
TAS
retrieved
27 February 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
ISO
retrieved
27 February 2018
stated in
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
IMP
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
IEA
retrieved
27 February 2018
stated in
AMPK phosphorylation of raptor mediates a metabolic checkpoint
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
IDA
retrieved
27 February 2018
stated in
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
IDA
retrieved
27 February 2018
stated in
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
IDA
retrieved
27 February 2018
stated in
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
IDA
protein serine/threonine kinase activity
determination method or standard
IEA
IMP
EXP
5 references
retrieved
27 February 2018
stated in
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
IMP
retrieved
27 February 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
IEA
retrieved
27 February 2018
stated in
Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
EXP
retrieved
27 February 2018
stated in
Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
EXP
retrieved
27 February 2018
stated in
Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BRK8&geneProductId=UniProtKB:Q8BRK8
determination method or standard
EXP
protein serine/threonine kinase activity
determination method or standard
EXP
IBA
IEA
IMP
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
ISO
retrieved
14 February 2019
stated in
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
IBA
retrieved
14 February 2019
stated in
Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
EXP
retrieved
14 February 2019
stated in
Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
EXP
retrieved
14 February 2019
stated in
Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
EXP
AMP-activated protein kinase activity
determination method or standard
IDA
IEA
IGI
IMP
ISO
TAS
10 references
retrieved
14 February 2019
stated in
Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
TAS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
ISO
retrieved
14 February 2019
stated in
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
IMP
retrieved
14 February 2019
stated in
Polarized activities of AMPK and BRSK in primary hippocampal neurons
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
IGI
retrieved
14 February 2019
stated in
AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
IEA
retrieved
14 February 2019
stated in
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
IDA
retrieved
14 February 2019
stated in
AMPK phosphorylation of raptor mediates a metabolic checkpoint
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
IDA
retrieved
14 February 2019
stated in
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
IDA
retrieved
14 February 2019
stated in
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
GOA
curator
UniProt
UniProt protein ID
Q8BRK8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BRK8
determination method or standard
IDA
cell component
biological process

Identifiers

 
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