(Q21499226)

English

Cathepsin D

mammalian protein found in Mus musculus

Ctsd
cathepsin D

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Aspartic peptidase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18242

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18242

Peptidase family A1 domain

1 reference

based on heuristic

inferred from protein domain or family

Aspartic peptidase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aspartic peptidase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

peptidase activity

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

8 April 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

8 April 2019

Lysosomal proteases are involved in generation of N-terminal huntingtin fragments

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

aspartic-type endopeptidase activity

determination method

3 references

aspartic-type endopeptidase activity

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Regulated renin release from 3T3-L1 adipocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

peptide binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

protein binding

determination method

1 reference

9 May 2019

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

aspartic-type peptidase activity

determination method

1 reference

9 May 2019

Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

peptidase activity

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Lysosomal proteases are involved in generation of N-terminal huntingtin fragments

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

extracellular matrix

determination method

1 reference

27 February 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

determination method

11 references

27 February 2018

Identification and subcellular localization of a new cystinosin isoform

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

II. Characterization and development of the regional- and cellular-specific abnormalities in the epididymis of mice with beta-hexosaminidase A deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

Identification and subcellular localization of a new cystinosin isoform

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

determination method

1 reference

27 February 2018

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

extracellular space

determination method

3 references

27 February 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

extracellular region

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

determination method

1 reference

9 May 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

determination method

13 references

9 May 2019

Identification and subcellular localization of a new cystinosin isoform

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

II. Characterization and development of the regional- and cellular-specific abnormalities in the epididymis of mice with beta-hexosaminidase A deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Identification and subcellular localization of a new cystinosin isoform

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

collagen-containing extracellular matrix

determination method

1 reference

9 May 2019

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

lysosomal membrane

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

endosome membrane

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

biological process

protein catabolic process

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

epithelial tube branching involved in lung morphogenesis

determination method

1 reference

9 May 2019

Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

autophagosome assembly

determination method

1 reference

9 May 2019

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

determination method

3 references

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

27 February 2018

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

determination method

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

lipoprotein catabolic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

positive regulation of apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

regulation of establishment of protein localization

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

determination method

Aspartic peptidase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18242

Peptidase family A1 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18242

Aspartic peptidase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18242

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000121203

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000121203

ENSMUSP00000063904

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000063904

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21499226&oldid=2023185651"