(Q21981066)

English

Eomesodermin

mammalian protein found in Mus musculus

Eomes
eomesodermin homolog
T-brain-2
TBR-2
T-box brain protein 2

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

p53-like transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54839

Transcription factor, T-box

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54839

T-box superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54839

T-box transcription factor-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transcription factor, T-box, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

9 May 2019

Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

chromatin binding

determination method

1 reference

9 May 2019

The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method

1 reference

9 May 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

molecular function regulator

determination method

1 reference

9 May 2019

Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

intracellular anatomical structure

determination method

1 reference

10 September 2018

The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54839&geneProductId=UniProtKB:O54839

determination method

determination method

7 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

9 May 2019

Eomesodermin is expressed in mouse oocytes and pre-implantation embryos

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

9 May 2019

The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

9 May 2019

Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

9 May 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

9 May 2019

Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

biological process

regulation of neuron differentiation

determination method

1 reference

14 February 2019

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

cell differentiation

determination method

4 references

9 May 2019

Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

9 May 2019

Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

9 May 2019

Eomesodermin is required for mouse trophoblast development and mesoderm formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

adaptive immune response

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

cerebral cortex regionalization

determination method

1 reference

9 May 2019

The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

endodermal cell fate specification

determination method

1 reference

9 May 2019

Pluripotency factors regulate definitive endoderm specification through eomesodermin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

immune system process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

cardioblast differentiation

determination method

1 reference

9 May 2019

The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54839&geneProductId=UniProtKB:O54839

determination method

mesodermal to mesenchymal transition involved in gastrulation

determination method

1 reference

9 May 2019

Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

stem cell population maintenance

determination method

1 reference

9 May 2019

Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

CD8-positive, alpha-beta T cell differentiation involved in immune response

determination method

3 references

regulation of gene expression

determination method

1 reference

9 May 2019

Pluripotency factors regulate definitive endoderm specification through eomesodermin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

skeletal muscle cell differentiation

determination method

1 reference

9 May 2019

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

cerebral cortex neuron differentiation

determination method

1 reference

9 May 2019

Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

olfactory bulb development

determination method

1 reference

9 May 2019

Atherosclerosis in LDLR-knockout mice is inhibited, but not reversed, by the PPARgamma ligand pioglitazone

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

endoderm formation

determination method

3 references

9 May 2019

Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

9 May 2019

Pluripotency factors regulate definitive endoderm specification through eomesodermin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

9 May 2019

The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

cell differentiation involved in embryonic placenta development

determination method

1 reference

9 May 2019

Eomesodermin is required for mouse trophoblast development and mesoderm formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

regulation of neurogenesis

determination method

1 reference

14 February 2019

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

blastocyst development

determination method

1 reference

9 May 2019

Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

negative regulation of DNA-binding transcription factor activity

determination method

1 reference

9 May 2019

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

determination method

1 reference

9 May 2019

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

neuron differentiation

determination method

1 reference

9 May 2019

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

endoderm development

determination method

1 reference

9 May 2019

Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

anatomical structure morphogenesis

determination method

1 reference

9 May 2019

Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

mesendoderm development

determination method

1 reference

9 May 2019

Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54839

determination method

Transcription factor, T-box, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54839

T-box transcription factor-associated

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54839

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000035020

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000035020

ENSMUSP00000107393

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000107393

ENSMUSP00000118079

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000118079

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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