(Q21981326)

Six-bladed beta-propeller, TolB-like

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Domain of unknown function DUF5050, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

Complement Clr-like EGF domain, protein family

1 reference

LDLR class B repeat, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

apolipoprotein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

clathrin heavy chain binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

protein-containing complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake

cargo receptor activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZX7&geneProductId=UniProtKB:Q91ZX7

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

integral component of plasma membrane

IEA

1 reference

8 April 2019

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

perinuclear region of cytoplasm

1 reference

8 April 2019

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

basolateral plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

clathrin-coated vesicle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

insulin-responsive compartment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

biological process

1 reference

8 April 2019

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

cardiac septum development

1 reference

8 April 2019

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

regulation of actin cytoskeleton organization

IEA

1 reference

8 April 2019

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

regulation of phospholipase A2 activity

1 reference

8 April 2019

LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

negative regulation of Wnt signaling pathway

1 reference

8 April 2019

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

negative regulation of smooth muscle cell migration

1 reference

8 April 2019

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of lipid transport

1 reference

8 April 2019

LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

cholesterol metabolic process

1 reference

8 April 2019

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

coronary vasculature development

1 reference

8 April 2019

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

regulation of cholesterol transport

1 reference

8 April 2019

LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release

apoptotic cell clearance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of cholesterol efflux

IEA

1 reference

8 April 2019

LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of lysosomal protein catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZX7&geneProductId=UniProtKB:Q91ZX7

positive regulation of cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of endocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of protein localization to plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

protein kinase C-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

negative regulation of neuron projection development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

negative regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of protein transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

astrocyte activation involved in immune response

1 reference

8 April 2019

LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

receptor-mediated endocytosis

IGI

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Neuronal clearance of amyloid-β by endocytic receptor LRP1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

negative regulation of cell-substrate adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of neuron projection development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

cellular lipid catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of axon extension

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of axon extension involved in regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of collateral sprouting of injured axon

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of phagocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

negative regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

negative regulation of focal adhesion assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

negative regulation of cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

chemoattraction of axon

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

amyloid-beta clearance by cellular catabolic process

3 references

1 January 2018

LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZX7&geneProductId=UniProtKB:Q91ZX7

1 January 2018

Neuronal clearance of amyloid-β by endocytic receptor LRP1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZX7&geneProductId=UniProtKB:Q91ZX7

1 January 2018

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZX7&geneProductId=UniProtKB:Q91ZX7

positive regulation of Schwann cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of cholesterol import

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

cellular response to amyloid-beta

1 reference

8 April 2019

LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

positive regulation of vascular associated smooth muscle cell migration

IGI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

1 reference

8 April 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

amyloid-beta clearance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

amyloid-beta clearance by transcytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

amyloid-beta clearance by cellular catabolic process

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Neuronal clearance of amyloid-β by endocytic receptor LRP1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

8 April 2019

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZX7

Domain of unknown function DUF5050

has part(s)

1 reference

EGF-like calcium-binding, conserved site

1 reference

EGF-like calcium-binding domain

1 reference

low-density lipoprotein (LDL) receptor class A repeat

1 reference

LDLR class B repeat

1 reference

EGF-like, conserved site

1 reference

Complement Clr-like EGF domain

1 reference

EGF-type aspartate/asparagine hydroxylation site

1 reference

EGF-like domain

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site

1 reference