(Q21982739)

http://www.ebi.ac.uk/interpro/protein/P34056

Transcription factor AP-2, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transcription factor AP-2 alpha, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein dimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

DNA-binding transcription factor activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Cloning and characterization of a novel mouse AP-2 transcription factor, AP-2delta, with unique DNA binding and transactivation properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

DNA-binding transcription activator activity, RNA polymerase II-specific

9 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

10 September 2018

Transcriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

10 September 2018

Cloning and characterization of a second AP-2 transcription factor: AP-2 beta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

10 September 2018

AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Transcriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Cloning and characterization of a second AP-2 transcription factor: AP-2 beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

DNA-binding transcription repressor activity, RNA polymerase II-specific

8 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

10 September 2018

Induction of dystrophin Dp71 expression during neuronal differentiation: opposite roles of Sp1 and AP2alpha in Dp71 promoter activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

10 September 2018

AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Induction of dystrophin Dp71 expression during neuronal differentiation: opposite roles of Sp1 and AP2alpha in Dp71 promoter activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

transcription coactivator activity

1 reference

24 April 2018

A heart-hand syndrome gene: Tfap2b plays a critical role in the development and remodeling of mouse ductus arteriosus and limb patterning

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

5 June 2018

Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

transcription corepressor activity

2 references

1 reference

14 February 2019

Cloning and characterization of a novel mouse AP-2 transcription factor, AP-2delta, with unique DNA binding and transactivation properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

sequence-specific DNA binding

IEA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

10 September 2018

Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

transcription coactivator activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Cloning and characterization of a second AP-2 transcription factor: AP-2 beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

A heart-hand syndrome gene: Tfap2b plays a critical role in the development and remodeling of mouse ductus arteriosus and limb patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

transcription cis-regulatory region binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

RNA polymerase II core promoter sequence-specific DNA binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

transcription factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

RNA polymerase II transcription regulatory region sequence-specific DNA binding

IBA

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

8 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

5 June 2018

Tbx3 is required for outflow tract development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

5 June 2018

Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

5 June 2018

AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

5 June 2018

Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2alpha

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

5 June 2018

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

intracellular membrane-bounded organelle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

transcription regulator complex

1 reference

14 February 2019

Cloning and characterization of a novel mouse AP-2 transcription factor, AP-2delta, with unique DNA binding and transactivation properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Tbx3 is required for outflow tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

negative regulation of neuron apoptotic process

IBA

biological process

1 reference

14 February 2019

The transcription factors AP-2β and AP-2α are required for survival of sympathetic progenitors and differentiated sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

anterior neuropore closure

IGI

1 reference

14 February 2019

Transcription factor AP-2 essential for cranial closure and craniofacial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

negative regulation of epidermal growth factor receptor signaling pathway

1 reference

14 February 2019

AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

embryonic pattern specification

1 reference

14 February 2019

Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

embryonic body morphogenesis

1 reference

14 February 2019

Loss of AP-2alpha impacts multiple aspects of ventral body wall development and closure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

regulation of transcription by RNA polymerase II

1 reference

5 June 2018

Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

trigeminal nerve development

1 reference

14 February 2019

Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

outflow tract morphogenesis

1 reference

14 February 2019

Requirement for AP-2alpha in cardiac outflow tract morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

forebrain neuron development

1 reference

14 February 2019

Transcription factor activator protein-2 is required for continued luteinizing hormone-releasing hormone expression in the forebrain of developing mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

positive regulation of neuron apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

1 reference

14 February 2019

AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice

forelimb morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

regulation of neuron differentiation

1 reference

14 February 2019

Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

2 references

optic vesicle morphogenesis

1 reference

14 February 2019

AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

positive regulation of transcription, DNA-templated

IEA

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

embryonic camera-type eye morphogenesis

1 reference

14 February 2019

AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

lens induction in camera-type eye

1 reference

14 February 2019

Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

basement membrane organization

1 reference

14 February 2019

Targeted deletion of AP-2alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

optic cup structural organization

1 reference

14 February 2019

AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

roof of mouth development

ISS

cornea development in camera-type eye

2 references

1 reference

14 February 2019

Targeted deletion of AP-2alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis

epidermis morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

skeletal system morphogenesis

1 reference

14 February 2019

Transcription factor AP-2 essential for cranial closure and craniofacial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

negative regulation of transcription by RNA polymerase II

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

A heart-hand syndrome gene: Tfap2b plays a critical role in the development and remodeling of mouse ductus arteriosus and limb patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

eyelid development in camera-type eye

1 reference

14 February 2019

AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

metanephric nephron development

1 reference

14 February 2019

Cloning and characterization of a second AP-2 transcription factor: AP-2 beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

nervous system development

IEP

1 reference

14 February 2019

Cloning and characterization of a second AP-2 transcription factor: AP-2 beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis

IEP

keratinocyte development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

sensory organ development

IGI

1 reference

14 February 2019

Cloning and characterization of a second AP-2 transcription factor: AP-2 beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

negative regulation of transcription, DNA-templated

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

embryonic forelimb morphogenesis

1 reference

14 February 2019

AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

cellular response to iron ion

ISS

sympathetic nervous system development

2 references

1 reference

14 February 2019

The transcription factors AP-2β and AP-2α are required for survival of sympathetic progenitors and differentiated sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

neural crest cell development

IGI

1 reference

14 February 2019

Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

positive regulation of cell migration

1 reference

14 February 2019

AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

1 reference

14 February 2019

Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

2 references

positive regulation of gene expression

1 reference

14 February 2019

Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

inner ear morphogenesis

ISS

regulation of cell differentiation

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

oculomotor nerve formation

1 reference

14 February 2019

Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

positive regulation of transcription by RNA polymerase II

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Transcriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Cloning and characterization of a second AP-2 transcription factor: AP-2 beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

14 February 2019

Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

transcription by RNA polymerase II

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056

response to lipopolysaccharide

IEA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056

Transcription factor AP-2, C-terminal

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P34056

Transcription factor AP-2 alpha, N-terminal

1 reference

stated in

InterPro Release 71.0