Wikidata

(Q21983331)

English

HNF1 homeobox A

mammalian protein found in Mus musculus

  • hepatocyte nuclear factor 1
  • liver-specific transcription factor LF-B1
  • TCF-1
  • Hnf1a
  • HNF-1A
  • HNF-1-alpha
  • hepatocyte nuclear factor 1-alpha
  • LFB1
  • transcription factor 1
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method
IPI
6 references
retrieved
9 May 2019
stated in
HNF1alpha controls renal glucose reabsorption in mouse and man.
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IPI
retrieved
9 May 2019
stated in
Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IPI
retrieved
9 May 2019
stated in
Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IPI
retrieved
9 May 2019
stated in
Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IPI
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IPI
retrieved
9 May 2019
stated in
A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IPI
DNA binding
determination method
ISO
IDA
IEA
25 references
retrieved
9 May 2019
stated in
Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
HNF1alpha controls renal glucose reabsorption in mouse and man.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Abnormal gene expression and regulation in the liver of jvs mice with systemic carnitine deficiency
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Plasticity and expanding complexity of the hepatic transcription factor network during liver development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
DNA-binding transcription factor activity
determination method
ISO
IDA
IMP
IEA
12 references
retrieved
16 July 2018
stated in
Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
ISO
retrieved
16 July 2018
stated in
Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
HNF1alpha controls renal glucose reabsorption in mouse and man.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
DNA-binding transcription factor activity
determination method
IBA
IDA
IEA
IMP
ISO
13 references
retrieved
9 May 2019
stated in
Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
ISO
retrieved
9 May 2019
stated in
Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
HNF1alpha controls renal glucose reabsorption in mouse and man.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IBA
cell component
nucleus
determination method
IDA
ISO
IEA
21 references
retrieved
16 July 2018
stated in
Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
ISO
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Immunological characterization of hepatocyte nuclear factor 1 protein: appearance of hepatocyte nuclear factor 1 protein in developing mouse embryos
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
HNF1alpha controls renal glucose reabsorption in mouse and man.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
HNF1alpha is involved in tissue-specific regulation of CFTR gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
ISO
22 references
retrieved
9 May 2019
stated in
Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
HNF1alpha controls renal glucose reabsorption in mouse and man.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Immunological characterization of hepatocyte nuclear factor 1 protein: appearance of hepatocyte nuclear factor 1 protein in developing mouse embryos
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
HNF1alpha is involved in tissue-specific regulation of CFTR gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IBA
biological process
positive regulation of transcription, DNA-templated
determination method
IDA
IMP
ISO
IEA
23 references
retrieved
16 July 2018
stated in
Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
ISO
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
16 July 2018
stated in
The role of HNF-1alpha in controlling hepatic catalase activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
16 July 2018
stated in
A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor 1alpha controls the expression of terminal complement genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
16 July 2018
stated in
HNF1alpha is involved in tissue-specific regulation of CFTR gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
16 July 2018
stated in
Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
16 July 2018
stated in
HNF1alpha controls renal glucose reabsorption in mouse and man.
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
HNF1alpha controls renal glucose reabsorption in mouse and man.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
HNF1alpha is involved in tissue-specific regulation of CFTR gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
16 July 2018
stated in
Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22361&geneProductId=UniProtKB:P22361
determination method
IDA
insulin secretion
determination method
IEA
IMP
ISO
6 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
ISO
retrieved
9 May 2019
stated in
Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IEA
positive regulation of transcription, DNA-templated
determination method
IBA
IDA
IEA
IMP
ISO
25 references
retrieved
9 May 2019
stated in
Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
ISO
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
The role of HNF-1alpha in controlling hepatic catalase activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
HNF1alpha is involved in tissue-specific regulation of CFTR gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor 1alpha controls the expression of terminal complement genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IEA
retrieved
9 May 2019
stated in
HNF1alpha controls renal glucose reabsorption in mouse and man.
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity
GOA
curator
UniProt
UniProt protein ID
P22361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
HNF1alpha controls renal glucose reabsorption in mouse and man.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
HNF1alpha is involved in tissue-specific regulation of CFTR gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22361
determination method
IBA

Identifiers

 
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