(Q21984268)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8VDL9

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

3 references

14 February 2019

14 February 2019

Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

14 February 2019

The transcriptional repressor Glis2 is a novel binding partner for p120 catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

27 March 2018

CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

DNA-binding transcription factor activity

1 reference

14 February 2019

Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

10 September 2018

Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

14 February 2019

Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

1 reference

14 February 2019

protein binding

IPI

nucleic acid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

1 reference

14 February 2019

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

cell component

nuclear speck

transcription regulator complex

1 reference

14 February 2019

Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

4 references

27 March 2018

27 March 2018

The transcriptional repressor Glis2 is a novel binding partner for p120 catenin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

27 March 2018

Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

27 March 2018

Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

non-motile cilium

1 reference

14 February 2019

Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

5 references

14 February 2019

14 February 2019

Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

14 February 2019

The transcriptional repressor Glis2 is a novel binding partner for p120 catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

14 February 2019

Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

biological process

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

1 reference

14 February 2019

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

1 reference

27 March 2018

negative regulation of smoothened signaling pathway

1 reference

14 February 2019

Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

kidney development

1 reference

14 February 2019

Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

negative regulation of transcription by RNA polymerase II

Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis

3 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

7 November 2018

Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

7 November 2018

Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

negative regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

1 reference

27 March 2018

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

1 reference

14 February 2019

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

1 reference

14 February 2019

positive regulation of transcription, DNA-templated

1 reference

14 February 2019

Characterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

cell differentiation involved in kidney development

1 reference

14 February 2019

Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

Characterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

positive regulation of transcription by RNA polymerase II

1 reference

7 November 2018

Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

positive regulation of protein localization to nucleus

IGI

1 reference

14 February 2019

The transcriptional repressor Glis2 is a novel binding partner for p120 catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

transcription by RNA polymerase II

IGI

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDL9&geneProductId=UniProtKB:Q8VDL9

negative regulation of transcription by RNA polymerase II

Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

14 February 2019

Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

14 February 2019

Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

central nervous system development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDL9

positive regulation of transcription by RNA polymerase II

has part(s)

Zinc finger C2H2-type

1 reference

InterPro Release 71.0