(Q28588215)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs (English)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

GLIS family zinc finger 2

9 February 2020

main subject

1 reference

SUFU negative regulator of hedgehog signaling

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Peter Igarashi

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Anton M. Jetten

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Massimo Attanasio

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Binghua Li

1

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Julie Dai

3

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Ramanavelan Sakthivel

4

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Alysha A Rauhauser

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

publication date

4 August 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

published in

Human Molecular Genetics

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

20

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

4155-4166

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

21

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

9 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3188992/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

17 March 2017

1 reference

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Cilia and Hedgehog responsiveness in the mouse

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Suppressor of fused regulates Gli activity through a dual binding mechanism

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

The Hedgehog response network: sensors, switches, and routers

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Characterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Hedgehog signaling in animal development: paradigms and principles

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

PAX2 suppresses apoptosis in renal collecting duct cells

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Altered neural cell fates and medulloblastoma in mouse patched mutants

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Genomic maps and comparative analysis of histone modifications in human and mouse

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Comparative analysis of the mammalian WNT4 promoter

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Cell and molecular biology of kidney development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Single-vector inducible lentiviral RNAi system for oncology target validation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Nephronophthisis: disease mechanisms of a ciliopathy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Genomic structure of the gene encoding the human GLI-related, Krüppel-like zinc finger protein GLIS2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Sequential cell and tissue interactions governing organogenesis of the kidney

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188992

Sufu recruits GSK3beta for efficient processing of Gli3.

3 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR339

Induction of neurogenin-1 expression by sonic hedgehog: Its role in development of trigeminal sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR339

Primary renal hypoplasia in humans and mice with PAX2 mutations: evidence of increased apoptosis in fetal kidneys of Pax2(1Neu) +/- mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR339

Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR339

Expression of Nuclear Transcription Factor PAX2 in Renal Biopsies of Juvenile Nephronophthisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR339

21 January 2018

Identifiers

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816948%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

2 references

31 January 2017