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(Q21984367)
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English
Complement component 1, q subcomponent, alpha polypeptide
mammalian protein found in Mus musculus
C1qa
complement C1q subcomponent subunit A
adiponectin c
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P98086
subclass of
protein
1 reference
stated in
UniProt
retrieved
19 January 2017
UniProt protein ID
P98086
part of
Tumour necrosis factor-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P98086
Complement C1q subcomponent subunit A
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P98086
C1q domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
collagen triple helix repeat, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P98086
encoded by
C1qa
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P98086
molecular function
protein binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IPI
cell component
extracellular region
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P98086
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IEA
collagen
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P98086
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IEA
extracellular space
determination method
IDA
1 reference
retrieved
31 January 2018
stated in
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P98086&geneProductId=UniProtKB:P98086
determination method
IDA
extracellular space
determination method
HDA
1 reference
retrieved
8 April 2019
stated in
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
HDA
synapse
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
The classical complement cascade mediates CNS synapse elimination
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IGI
postsynapse
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Complement and microglia mediate early synapse loss in Alzheimer mouse models.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IGI
amyloid-beta complex
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IGI
biological process
response to iron ion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IEA
innate immune response
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P98086
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IEA
immune system process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P98086
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IEA
complement activation, classical pathway
determination method
IEA
IMP
3 references
retrieved
8 April 2019
stated in
Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P98086
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IEA
human ageing
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IGI
neuron remodeling
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The classical complement cascade mediates CNS synapse elimination
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IMP
synapse organization
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Complement and microglia mediate early synapse loss in Alzheimer mouse models.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IGI
positive regulation of astrocyte activation
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IGI
synapse pruning
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Complement and microglia mediate early synapse loss in Alzheimer mouse models.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IGI
complement-mediated synapse pruning
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The classical complement cascade mediates CNS synapse elimination
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IMP
vertebrate eye-specific patterning
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The classical complement cascade mediates CNS synapse elimination
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IMP
positive regulation of neuron death
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IGI
positive regulation of microglial cell activation
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98086
determination method
IGI
has part(s)
C1q domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P98086
Collagen triple helix repeat
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P98086
Identifiers
RefSeq protein ID
NP_031598
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
12259
UniProt protein ID
P98086
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P98086
Ensembl protein ID
ENSMUSP00000048836
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000048836
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