(Q44241464)

1 December 2017

Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729885&resulttype=core&format=json

12 May 2020

main subject

Complement C1q A chain

1 reference

GOA release 2020-03-11

amyloid-beta binding

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Complement component 1, q subcomponent, alpha polypeptide

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

3

Marina Botto

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author name string

Maria Isabel Fonseca

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729885&resulttype=core&format=json

12 May 2020

Jun Zhou

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729885&resulttype=core&format=json

12 May 2020

Marina Botto

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729885&resulttype=core&format=json

12 May 2020

Andrea J Tenner

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729885&resulttype=core&format=json

12 May 2020

language of work or name

English

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publication date

1 July 2004

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1 December 2017

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729885&resulttype=core&format=json

12 May 2020

volume

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729885&resulttype=core&format=json

12 May 2020

page(s)

6457-6465

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729885&resulttype=core&format=json

12 May 2020

issue

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729885&resulttype=core&format=json

Membrane receptors for soluble defense collagens

12 May 2020

cites work

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12 December 2020

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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12 December 2020

Inflammation of the brain in Alzheimer's disease: implications for therapy.

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12 December 2020

Association of microglia with amyloid plaques in brains of APP23 transgenic mice

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12 December 2020

The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age.

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12 December 2020

The mouse C1q A-chain sequence alters beta-amyloid-induced complement activation

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12 December 2020

Complement component C1q modulates the phagocytosis of Abeta by microglia

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12 December 2020

Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia.

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12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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12 December 2020

Inflammation and Alzheimer's disease

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12 December 2020

1 reference

12 December 2020

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

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12 December 2020

The C5a complement activation peptide increases IL-1beta and IL-6 release from amyloid-beta primed human monocytes: implications for Alzheimer's disease

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12 December 2020

Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice

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12 December 2020

Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology

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12 December 2020

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

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12 December 2020

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

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12 December 2020

Spatial long-term memory is related to mossy fiber synaptogenesis.

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12 December 2020

Immunological aspects of microglia: relevance to Alzheimer's disease

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12 December 2020

Complement in Alzheimer's disease: opportunities for modulating protective and pathogenic events

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12 December 2020

Learning and memory in transgenic mice modeling Alzheimer's disease

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12 December 2020

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

1 reference

12 December 2020

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

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12 December 2020

Reversal of amyloid beta toxicity in Alzheimer's disease model Tg2576 by intraventricular antiamyloid beta antibody.

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12 December 2020

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

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12 December 2020

Inflammation in neurodegenerative disease--a double-edged sword

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12 December 2020

Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease

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12 December 2020

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

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12 December 2020

Increased fibrillar beta-amyloid in response to human clq injections into hippocampus and cortex of APP+PS1 transgenic mice

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12 December 2020

Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection

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12 December 2020

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

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12 December 2020

Complement mRNA in the mammalian brain: responses to Alzheimer's disease and experimental brain lesioning

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12 December 2020

Complement activation by beta-amyloid in Alzheimer disease

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12 December 2020

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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12 December 2020

Chemotaxis by a CNS macrophage, the microglia

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12 December 2020

Complement activation in amyloid plaques in Alzheimer's dementia.

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12 December 2020

Mouse strains with typical mammalian levels of complement activity

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12 December 2020

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

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12 December 2020

Interaction of cells with immune complexes: adherence, release of constituents, and tissue injury

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12 December 2020

Expression of C1q, a subcomponent of the rat complement system, is dramatically enhanced in brains of rats with either Borna disease or experimental allergic encephalomyelitis

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12 December 2020

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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12 December 2020

Enhanced aggregation and beta structure of amyloid beta peptide after coincubation with C1q.

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12 December 2020

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

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12 December 2020

Synaptic and neuritic alterations during the progression of Alzheimer's disease

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12 December 2020

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

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12 December 2020

Multivalent binding of complement protein C1Q to the amyloid beta-peptide (A beta) promotes the nucleation phase of A beta aggregation.

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12 December 2020

Localization and cell association of C1q in Alzheimer's disease brain

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12 December 2020

Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine

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12 December 2020

Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

beta-Amyloid converts an acute phase injury response to chronic injury responses

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12 December 2020

Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions

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12 December 2020

Aspartate residue 7 in amyloid beta-protein is critical for classical complement pathway activation: implications for Alzheimer's disease pathogenesis

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12 December 2020

Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system.

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12 December 2020

Kainic acid and decorticating lesions stimulate the synthesis of C1q protein in adult rat brain.

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12 December 2020

The mean A beta load in the hippocampus correlates with duration and severity of dementia in subgroups of Alzheimer disease.

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12 December 2020

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited

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12 December 2020

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

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12 December 2020

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

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12 December 2020

Life and death of neurons in the aging brain

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12 December 2020

Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease.

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12 December 2020

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

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12 December 2020

Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain.

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12 December 2020

Microglial response to amyloid plaques in APPsw transgenic mice.

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12 December 2020

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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12 December 2020

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

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12 December 2020

The importance of inflammatory mechanisms in Alzheimer disease.

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12 December 2020

Long-term but not short-term plasticity at mossy fiber synapses is impaired in neural cell adhesion molecule-deficient mice

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12 December 2020

Neuron loss in APP transgenic mice

1 reference

12 December 2020

10.1523/JNEUROSCI.0901-04.2004

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729885&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729885&resulttype=core&format=json

12 May 2020

1 reference