(Q21984422)

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

1 reference

14 February 2019

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

receptor antagonist activity

IPI

2 references

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

3 references

receptor antagonist activity

3 references

3 references

hair follicle development

1 reference

14 February 2019

The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

Wnt signaling pathway involved in somitogenesis

1 reference

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

1 reference

14 February 2019

Dkk1 and Wnt3 interact to control head morphogenesis in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

1 reference

14 February 2019

Dkk1 and Wnt3 interact to control head morphogenesis in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

response to retinoic acid

IGI

1 reference

14 February 2019

Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

negative regulation of Wnt-Frizzled-LRP5/6 complex assembly

3 references

14 February 2019

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway

1 reference

14 February 2019

MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

negative regulation of Wnt signaling pathway

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Wnt signaling mediates regional specification in the vertebrate face

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Macrophage Wnt7b is critical for kidney repair and regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

1 reference

14 February 2019

ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

negative regulation of transcription by RNA polymerase II

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Wnt-beta-catenin signaling initiates taste papilla development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

Wnt signaling pathway

1 reference

14 February 2019

negative regulation of BMP signaling pathway

1 reference

14 February 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

multicellular organism development

2 references

1 reference

14 February 2019

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

regulation of Wnt signaling pathway

1 reference

14 February 2019

Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

embryonic limb morphogenesis

1 reference

14 February 2019

En1 and Wnt7a interact with Dkk1 during limb development in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

negative regulation of skeletal muscle tissue development

IGI

1 reference

14 February 2019

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse

forebrain development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

cell morphogenesis involved in differentiation

IGI

1 reference

14 February 2019

Dkk1 and Wnt3 interact to control head morphogenesis in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

1 reference

14 February 2019

ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

regulation of synaptic transmission, glutamatergic

1 reference

14 February 2019

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

regulation of synapse organization

1 reference

14 February 2019

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

negative regulation of canonical Wnt signaling pathway

12 references

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

Dkk1 and Wnt3 interact to control head morphogenesis in the mouse

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

Dkk1 and Wnt3 interact to control head morphogenesis in the mouse

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

Wnt-beta-catenin signaling initiates taste papilla development

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

31 January 2017

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O54908

1 reference

14 February 2019

Wnt signaling mediates regional specification in the vertebrate face

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

extracellular negative regulation of signal transduction

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54908&geneProductId=UniProtKB:O54908

positive regulation of midbrain dopaminergic neuron differentiation

1 reference

14 February 2019

Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

1 reference

14 February 2019

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

positive regulation of gene expression

3 references

negative regulation of ossification

1 reference

14 February 2019

Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

negative regulation of apoptotic process

1 reference

14 February 2019

Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

1 reference

14 February 2019

Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

negative regulation of canonical Wnt signaling pathway

14 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Dkk1 and Wnt3 interact to control head morphogenesis in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Dkk1 and Wnt3 interact to control head morphogenesis in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Wnt-beta-catenin signaling initiates taste papilla development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

positive regulation of tau-protein kinase activity

IBA

1 reference

14 February 2019

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

negative regulation of neuron projection development

1 reference

14 February 2019

miRNA-431 Prevents Amyloid-β-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer's Disease by Silencing Kremen1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

negative regulation of presynapse assembly

1 reference

14 February 2019

miRNA-431 Prevents Amyloid-β-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer's Disease by Silencing Kremen1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908

negative regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54908