(Q21984626)

http://www.ebi.ac.uk/interpro/protein/A2ARI4

Glycoprotein hormone receptor family

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/A2ARI4

membrane protein

1 reference

inferred from GOA cell component → membrane

Leucine-rich repeat N-terminal domain, protein family

1 reference

GPCR, rhodopsin-like, 7TM, protein family

1 reference

Leucine-rich repeat, typical subtype, protein family

1 reference

Leucine-rich repeat, protein family

1 reference

G protein-coupled receptor activity

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

signal transducer activity

IDA

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=A2ARI4&geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

transmembrane signaling receptor activity

IPI

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

9 May 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

protein-hormone receptor activity

IDA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

integral component of plasma membrane

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

9 May 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

positive regulation of branching involved in ureteric bud morphogenesis

1 reference

9 May 2019

Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

male genitalia development

1 reference

9 May 2019

Defective postnatal development of the male reproductive tract in LGR4 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

metanephric nephron tubule morphogenesis

1 reference

9 May 2019

Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

immune system process

1 reference

9 May 2019

metanephric glomerulus development

1 reference

9 May 2019

Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

positive regulation of canonical Wnt signaling pathway

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

9 May 2019

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

9 May 2019

Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

9 May 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

epithelial cell proliferation

IDA

1 reference

9 May 2019

Defective postnatal development of the male reproductive tract in LGR4 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

Wnt signaling pathway

1 reference

9 May 2019

1 reference

9 May 2019

Defective postnatal development of the male reproductive tract in LGR4 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

circadian regulation of gene expression

1 reference

9 May 2019

LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

positive regulation of transcription, DNA-templated

1 reference

9 May 2019

Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

cell differentiation involved in metanephros development

1 reference

9 May 2019

Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

intestinal stem cell homeostasis

1 reference

9 May 2019

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

negative regulation of toll-like receptor signaling pathway

1 reference

9 May 2019

Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

epithelial cell proliferation involved in renal tubule morphogenesis

1 reference

9 May 2019

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

osteoblast differentiation

IEP

1 reference

9 May 2019

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

canonical Wnt signaling pathway involved in metanephric kidney development

1 reference

9 May 2019

Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

digestive tract development

1 reference

9 May 2019

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

innate immune response

1 reference

9 May 2019

negative regulation of transcription, DNA-templated

1 reference

9 May 2019

Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

negative regulation of cold-induced thermogenesis

1 reference

9 May 2019

Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARI4