(Q46519761)

22 December 2017

title

Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch (English)

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22 December 2017

Leucine rich repeat containing G protein-coupled receptor 4

main subject

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negative regulation of cold-induced thermogenesis

GOA release 2020-03-11

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Leucine-rich repeat-containing G protein-coupled receptor 4

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Jiqiu Wang

1

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author name string

Ruixin Liu

2

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22 December 2017

Feng Wang

3

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22 December 2017

Jie Hong

4

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22 December 2017

Xiaoying Li

5

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22 December 2017

Maopei Chen

6

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22 December 2017

Yingying Ke

7

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22 December 2017

Xianfeng Zhang

8

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22 December 2017

Qinyun Ma

9

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22 December 2017

Rui Wang

10

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22 December 2017

Juan Shi

11

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22 December 2017

Bin Cui

12

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22 December 2017

Weiqiong Gu

13

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22 December 2017

Yifei Zhang

14

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22 December 2017

Zhiguo Zhang

15

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22 December 2017

Weiqing Wang

16

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22 December 2017

Xuefeng Xia

17

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22 December 2017

Mingyao Liu

18

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22 December 2017

Guang Ning

19

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22 December 2017

publication date

10 November 2013

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22 December 2017

published in

Nature Cell Biology

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22 December 2017

volume

15

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22 December 2017

page(s)

1455-1463

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22 December 2017

issue

12

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22 December 2017

https://scigraph.springernature.com/pub.10.1038/ncb2867

exact match

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cites work

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CRTC3 links catecholamine signalling to energy balance

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Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes

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Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human

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Bi-directional interconversion of brite and white adipocytes

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Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse

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Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha

21 January 2018

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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

21 January 2018

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Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells

21 January 2018

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

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Identification of stem cells in small intestine and colon by marker gene Lgr5

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G protein-coupled receptor 48 upregulates estrogen receptor alpha expression via cAMP/PKA signaling in the male reproductive tract.

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GPR48 increases mineralocorticoid receptor gene expression

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Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

21 January 2018

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Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci

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Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

21 January 2018

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Rb regulates fate choice and lineage commitment in vivo

21 January 2018

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Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice.

21 January 2018

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MyoD stimulates RB promoter activity via the CREB/p300 nuclear transduction pathway.

21 January 2018

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Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region

21 January 2018

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A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty

21 January 2018

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Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorrhea.

21 January 2018

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Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations.

21 January 2018

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Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects

21 January 2018

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Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality

21 January 2018

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Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

21 January 2018

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Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

21 January 2018

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Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha

21 January 2018

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Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice

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The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts

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Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits

21 January 2018

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Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

21 January 2018

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Ginsenoside Re reduces insulin resistance through inhibition of c-Jun NH2-terminal kinase and nuclear factor-kappaB.

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21 January 2018

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A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty

21 January 2018

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12 December 2020

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

1 reference

12 December 2020

1 reference

12 December 2020

A simple method for the isolation and purification of total lipides from animal tissues

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCB2867

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22 December 2017

Dimensions Publication ID

0 references

1 reference

22 December 2017