(Q21984627)

English

Legumain

mammalian protein found in Mus musculus

asparaginyl endopeptidase
preprolegumain
legumain
Protease, cysteine 1
Lgmn
protease, cysteine, 1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Peptidase C13, legumain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O89017

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

peptidase activity

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

cysteine-type endopeptidase activity

determination method

1 reference

31 January 2018

Cloning and expression of mouse legumain, a lysosomal endopeptidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O89017&geneProductId=UniProtKB:O89017

determination method

cysteine-type peptidase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

hydrolase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

cysteine-type endopeptidase activity

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Cloning and expression of mouse legumain, a lysosomal endopeptidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Asparaginyl endopeptidase cleaves TDP-43 in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

determination method

1 reference

14 February 2019

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

apical part of cell

determination method

1 reference

14 February 2019

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Cloning and expression of mouse legumain, a lysosomal endopeptidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

biological process

negative regulation of multicellular organism growth

determination method

1 reference

14 February 2019

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

vacuolar protein processing

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

negative regulation of ERBB signaling pathway

determination method

1 reference

14 February 2019

Asparagine endopeptidase is required for normal kidney physiology and homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

renal system process

determination method

1 reference

14 February 2019

Asparagine endopeptidase is required for normal kidney physiology and homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

proteolysis involved in cellular protein catabolic process

determination method

1 reference

31 January 2018

Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O89017&geneProductId=UniProtKB:O89017

determination method

receptor catabolic process

determination method

1 reference

14 February 2019

Asparagine endopeptidase is required for normal kidney physiology and homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

determination method

5 references

14 February 2019

Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Cloning and expression of mouse legumain, a lysosomal endopeptidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

response to acidic pH

determination method

1 reference

31 January 2018

Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O89017&geneProductId=UniProtKB:O89017

determination method

determination method

1 reference

14 February 2019

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

associative learning

determination method

1 reference

14 February 2019

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

response to acidic pH

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

proteolysis involved in cellular protein catabolic process

determination method

dendritic spine organization

determination method

1 reference

14 February 2019

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

self proteolysis

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

positive regulation of long-term synaptic potentiation

determination method

1 reference

14 February 2019

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O89017

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000021607

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000021607

ENSMUSP00000105647

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000105647

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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