(Q21985207)

EF-hand domain pair

1 reference

Voltage-dependent channel domain superfamily

1 reference

EF-hand domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Polycystin cation channel, PKD1/PKD2, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

signaling receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

1 reference

9 May 2019

Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

10 references

9 May 2019

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Nek8 regulates the expression and localization of polycystin-1 and polycystin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Molecular cloning, genomic structure, and protein characterization of mouse optineurin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

1 reference

9 May 2019

Polycystin-2 is regulated by endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

voltage-gated ion channel activity

IPI

identical protein binding

ISO

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

outward rectifier potassium channel activity

1 reference

9 May 2019

The native TRPP2-dependent channel of murine renal primary cilia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

calcium channel activity

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

24 April 2018

The native TRPP2-dependent channel of murine renal primary cilia

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

24 April 2018

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

potassium channel activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

calcium channel activity

6 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

7 November 2018

The native TRPP2-dependent channel of murine renal primary cilia

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

7 November 2018

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

cation channel activity

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

calcium channel activity

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

The native TRPP2-dependent channel of murine renal primary cilia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

signaling receptor binding

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

voltage-gated calcium channel activity

voltage-gated sodium channel activity

potassium channel activity

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

muscle alpha-actinin binding

1 reference

9 May 2019

Alpha-actinin associates with polycystin-2 and regulates its channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 references

14 February 2019

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

14 February 2019

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

14 February 2019

Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

14 February 2019

A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

14 February 2019

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

14 February 2019

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

14 February 2019

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

14 February 2019

Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2

endoplasmic reticulum

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

integral component of membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

endoplasmic reticulum membrane

1 reference

9 May 2019

Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

1 reference

9 May 2019

Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

basolateral plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

cytoplasmic vesicle membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

1 reference

7 November 2018

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

integral component of plasma membrane

cation channel complex

12 references

9 May 2019

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

metanephric S-shaped body morphogenesis

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

calcium ion transport

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

renal tubule morphogenesis

1 reference

9 May 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

renal system development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

mesonephric tubule development

IGI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

metanephric cortex development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

metanephric ascending thin limb development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

branching involved in ureteric bud morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

neural tube development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

spinal cord development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

release of sequestered calcium ion into cytosol

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

metanephric distal tubule development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

cellular calcium ion homeostasis

1 reference

9 May 2019

Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

cellular response to fluid shear stress

3 references

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.

detection of nodal flow

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

metanephric mesenchyme development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

renal artery morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

receptor signaling pathway via JAK-STAT

1 reference

9 May 2019

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

metanephric cortical collecting duct development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

mesonephric duct development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

positive regulation of nitric oxide biosynthetic process

3 references

placenta blood vessel development

1 reference

9 May 2019

Pkd1 and Pkd2 are required for normal placental development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

negative regulation of ryanodine-sensitive calcium-release channel activity

1 reference

9 May 2019

Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

determination of left/right symmetry

1 reference

9 May 2019

The ion channel polycystin-2 is required for left-right axis determination in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

positive regulation of gene expression

1 reference

9 May 2019

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

metanephric part of ureteric bud development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

detection of mechanical stimulus

1 reference

24 April 2018

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

metanephric smooth muscle tissue development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

calcium ion transmembrane transport

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

The native TRPP2-dependent channel of murine renal primary cilia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

cellular response to calcium ion

1 reference

9 May 2019

The native TRPP2-dependent channel of murine renal primary cilia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

potassium ion transport

1 reference

9 May 2019

regulation of ion transmembrane transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

potassium ion transmembrane transport

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

The native TRPP2-dependent channel of murine renal primary cilia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

inorganic cation transmembrane transport

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

Wnt signaling pathway

1 reference

9 May 2019

positive regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245

protein heterotetramerization

protein tetramerization

cell-cell signaling by wnt

release of sequestered calcium ion into cytosol

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

potassium ion transmembrane transport

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

The native TRPP2-dependent channel of murine renal primary cilia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245

polycystin cation channel, PKD1/PKD2

has part(s)

1 reference

EF-hand domain

1 reference