(Q21986028)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

3 references

9 May 2019

CDK4 is an essential insulin effector in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

IPI

insulin receptor binding

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

phosphatidylinositol 3-kinase binding

IBA

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

21 June 2018

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

phosphatidylinositol 3-kinase binding

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

21 June 2018

Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

1 reference

21 June 2018

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

protein-containing complex

1 reference

9 May 2019

CDK4 is an essential insulin effector in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

regulation of lipid metabolic process

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

cellular response to insulin stimulus

IBA

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

positive regulation of cell population proliferation

1 reference

14 February 2019

Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

cellular response to peptide

IGI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

positive regulation of mesenchymal cell proliferation

1 reference

9 May 2019

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

negative regulation of B cell apoptotic process

IGI

1 reference

9 May 2019

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

negative regulation of kinase activity

IMP

1 reference

9 May 2019

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

1 reference

9 May 2019

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

cellular response to glucose stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

positive regulation of cell migration

1 reference

9 May 2019

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

1 reference

9 May 2019

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

positive regulation of B cell proliferation

IMP

1 reference

9 May 2019

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

cell population proliferation

1 reference

14 February 2019

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

positive regulation of insulin secretion

1 reference

9 May 2019

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

mammary gland development

IMP

1 reference

9 May 2019

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

insulin receptor signaling pathway

IGI

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

21 June 2018

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122

insulin receptor signaling pathway

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122