(Q21987288)

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox domain, metazoa, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

3 references

14 February 2019

TAZ interacts with TTF-1 and regulates expression of surfactant protein-C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

intronic transcription regulatory region sequence-specific DNA binding

IPI

1 reference

14 February 2019

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

transcription factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

sequence-specific DNA binding

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

RNA polymerase II transcription regulatory region sequence-specific DNA binding

3 references

14 February 2019

Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

DNA-binding transcription factor activity

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

TBP-class protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

protein homodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

RNA polymerase II cis-regulatory region sequence-specific DNA binding

2 references

1 January 2018

Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

14 February 2019

Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

DNA-binding transcription factor activity, RNA polymerase II-specific

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

sequence-specific DNA binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

transcription regulator complex

cell component

3 references

14 February 2019

TAZ interacts with TTF-1 and regulates expression of surfactant protein-C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

16 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Calcineurin/Nfat signaling is required for perinatal lung maturation and function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Immunolocalization of sonic hedgehog (Shh) in developing mouse lung

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

2 references

17 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Calcineurin/Nfat signaling is required for perinatal lung maturation and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Immunolocalization of sonic hedgehog (Shh) in developing mouse lung

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

cerebral cortex cell migration

biological process

1 reference

14 February 2019

Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

neuron fate commitment

telencephalon development

1 reference

14 February 2019

The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo

lung saccule development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 reference

14 February 2019

Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons

hippocampus development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

regulation of transcription by RNA polymerase II

1 reference

14 February 2019

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

pituitary gland development

1 reference

14 February 2019

Formation of Rathke's pouch requires dual induction from the diencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

forebrain dorsal/ventral pattern formation

3 references

14 February 2019

Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

Leydig cell differentiation

1 reference

14 February 2019

Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

telencephalon cell migration

positive regulation of circadian rhythm

1 reference

14 February 2019

Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

type II pneumocyte differentiation

1 reference

14 February 2019

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

pattern specification process

1 reference

14 February 2019

Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

anatomical structure formation involved in morphogenesis

1 reference

14 February 2019

Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

club cell differentiation

1 reference

14 February 2019

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

forebrain neuron differentiation

1 reference

14 February 2019

Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

1 reference

14 February 2019

Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

animal organ morphogenesis

1 reference

14 February 2019

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

Formation of Rathke's pouch requires dual induction from the diencephalon

developmental induction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

phospholipid metabolic process

1 reference

14 February 2019

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

negative regulation of transcription by RNA polymerase II

3 references

14 February 2019

Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

globus pallidus development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Regulation of lung endoderm progenitor cell behavior by miR302/367

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

thyroid gland development

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

An integrated regulatory network controlling survival and migration in thyroid organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

A mouse model demonstrates a multigenic origin of congenital hypothyroidism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

forebrain development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

positive regulation of transcription, DNA-templated

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

TAZ interacts with TTF-1 and regulates expression of surfactant protein-C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Characterization of a novel loss of function mutation of PAX8 in a familial case of congenital hypothyroidism with in-place, normal-sized thyroid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

positive regulation of transcription by RNA polymerase II

16 references

1 January 2018

TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Calcineurin/Nfat signaling is required for perinatal lung maturation and function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

SPDEF regulates goblet cell hyperplasia in the airway epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

NKX2.1 specifies cortical interneuron fate by activating Lhx6

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

TTF-1/NKX2.1 up-regulates the in vivo transcription of nestin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

1 January 2018

TAZ interacts with TTF-1 and regulates expression of surfactant protein-C

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220

epithelial tube branching involved in lung morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

regulation of blood volume by renin-angiotensin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

regulation of transcription, DNA-templated

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

response to lipopolysaccharide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

hyperosmotic salinity response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

positive regulation of transcription by RNA polymerase II

17 references

14 February 2019

TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

SPDEF regulates goblet cell hyperplasia in the airway epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Calcineurin/Nfat signaling is required for perinatal lung maturation and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

TTF-1/NKX2.1 up-regulates the in vivo transcription of nestin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

NKX2.1 specifies cortical interneuron fate by activating Lhx6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

TAZ interacts with TTF-1 and regulates expression of surfactant protein-C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220

1 reference

Homeobox, conserved site

1 reference

stated in

Homeobox domain, metazoa

1 reference

stated in