(Q21988090)

http://www.ebi.ac.uk/interpro/protein/Q64124

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

sequence-specific DNA binding

1 reference

14 February 2019

Scleraxis messenger ribonucleic acid is expressed in C2C12 myoblasts and its level is down-regulated by bone morphogenetic protein-2 (BMP2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

protein dimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

bHLH transcription factor binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

11 October 2018

Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64124&geneProductId=UniProtKB:Q64124

14 February 2019

Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

1 reference

14 February 2019

Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

protein heterodimerization activity

IPI

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

transcription regulator complex

cell component

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

cellular response to transforming growth factor beta stimulus

biological process

positive regulation of collagen biosynthetic process

1 reference

14 February 2019

Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

regulation of transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64124&geneProductId=UniProtKB:Q64124

chondrocyte differentiation

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

regulation of cartilage development

1 reference

14 February 2019

Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

positive regulation of gastrulation

1 reference

14 February 2019

Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

collagen fibril organization

1 reference

14 February 2019

Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

1 reference

14 February 2019

Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

tendon cell differentiation

1 reference

14 February 2019

Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

cellular response to BMP stimulus

1 reference

14 February 2019

Scleraxis messenger ribonucleic acid is expressed in C2C12 myoblasts and its level is down-regulated by bone morphogenetic protein-2 (BMP2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

negative regulation of apoptotic process

1 reference

14 February 2019

Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

Sertoli cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

endochondral ossification

ISS

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

BMP signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

transcription, DNA-templated

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Scleraxis messenger ribonucleic acid is expressed in C2C12 myoblasts and its level is down-regulated by bone morphogenetic protein-2 (BMP2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis

sclerotome development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

embryonic skeletal system development

1 reference

14 February 2019

Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

positive regulation of transcription, DNA-templated

deltoid tuberosity development

cellular response to mechanical stimulus

1 reference

14 February 2019

Mechanical force modulates scleraxis expression in bioartificial tendons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription

cartilage development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

positive regulation of gene expression

NAS

4 references

14 February 2019

Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo

heart valve formation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

positive regulation of cartilage development

1 reference

14 February 2019

Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

heart valve morphogenesis

1 reference

14 February 2019

Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

1 reference

14 February 2019

Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

positive regulation of cell population proliferation

1 reference

14 February 2019

Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

skeletal muscle cell differentiation

1 reference

14 February 2019

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

1 reference

14 February 2019

The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

positive regulation of transcription by RNA polymerase II

4 references

14 February 2019

Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

14 February 2019

Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64124

transcription by RNA polymerase II

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64124&geneProductId=UniProtKB:Q64124

Myc-type, basic helix-loop-helix (bHLH) domain

has part(s)

1 reference

stated in

InterPro Release 71.0