(Q21988557)

English

Sestrin 2

mammalian protein found in Mus musculus

sestrin-2
Sesn2

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58043

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58043

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

sulfiredoxin activity

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

peroxiredoxin activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

leucine binding

determination method

oxidoreductase activity, acting on peroxide as acceptor

determination method

oxidoreductase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

GDP-dissociation inhibitor activity

determination method

1 reference

14 February 2019

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

oxidoreductase activity, acting on peroxide as acceptor

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

leucine binding

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

determination method

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

determination method

nucleotide-activated protein kinase complex

determination method

1 reference

14 February 2019

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

determination method

1 reference

27 March 2018

Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043

determination method

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

Atg1/ULK1 kinase complex

determination method

3 references

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

biological process

fatty acid beta-oxidation

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

mitochondrion organization

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

regulation of response to reactive oxygen species

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

mitochondrial DNA metabolic process

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

protein kinase B signaling

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

glucose homeostasis

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

triglyceride homeostasis

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

regulation of cAMP-dependent protein kinase activity

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

negative regulation of cell growth

determination method

1 reference

14 February 2019

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

cellular oxidant detoxification

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

cellular response to amino acid stimulus

determination method

3 references

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043

determination method

27 March 2018

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043

determination method

reactive oxygen species metabolic process

determination method

3 references

negative regulation of TORC1 signaling

determination method

4 references

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043

determination method

27 March 2018

Hepatoprotective role of Sestrin2 against chronic ER stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043

determination method

27 March 2018

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043

determination method

cellular response to oxidative stress

determination method

1 reference

14 February 2019

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

DNA damage response, signal transduction by p53 class mediator

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

regulation of protein phosphorylation

determination method

positive regulation of macroautophagy

determination method

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

determination method

3 references

positive regulation of protein localization to nucleus

determination method

3 references

negative regulation of translation in response to endoplasmic reticulum stress

determination method

3 references

positive regulation of lipophagy

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

cellular response to leucine starvation

determination method

regulation of gluconeogenesis

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

positive regulation of macroautophagy

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

cellular response to amino acid stimulus

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

cellular response to leucine

determination method

3 references

negative regulation of TORC1 signaling

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Hepatoprotective role of Sestrin2 against chronic ER stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

cellular response to leucine starvation

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000030724

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000030724

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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