(Q21988969)

English

Presenilin 2

mammalian protein found in Mus musculus

presenilin-2
Psen2

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Peptidase A22A, presenilin 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61144

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

aspartic-type endopeptidase activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

endopeptidase activity

determination method

3 references

27 March 2018

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

27 March 2018

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

27 March 2018

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

peptidase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

hydrolase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

aspartic endopeptidase activity, intramembrane cleaving

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

endopeptidase activity

determination method

4 references

14 February 2019

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

integral component of membrane

determination method

2 references

ciliary basal body

determination method

1 reference

14 February 2019

A role for the primary cilium in Notch signaling and epidermal differentiation during skin development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

14 February 2019

Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

Golgi apparatus

determination method

3 references

endoplasmic reticulum membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

plasma membrane

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

integral component of plasma membrane

determination method

3 references

nuclear inner membrane

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

neuronal cell body

determination method

1 reference

27 March 2018

Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

27 March 2018

Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

endoplasmic reticulum

determination method

4 references

27 March 2018

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

27 March 2018

An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

perinuclear region of cytoplasm

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

mitochondrial inner membrane

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

lysosomal membrane

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

neuromuscular junction

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

ciliary rootlet

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

dendritic shaft

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

determination method

6 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

protein-containing complex

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

endoplasmic reticulum

determination method

3 references

apical plasma membrane

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

integral component of presynaptic membrane

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

plasma membrane

determination method

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

synaptic vesicle

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

synaptic membrane

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

biological process

negative regulation of protein phosphorylation

determination method

1 reference

14 February 2019

Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

hair follicle development

determination method

1 reference

14 February 2019

Mice lacking both presenilin genes exhibit early embryonic patterning defects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

myeloid leukocyte differentiation

determination method

1 reference

14 February 2019

Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method

1 reference

14 February 2019

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

intracellular signal transduction

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

skin morphogenesis

determination method

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

cardiac muscle contraction

determination method

1 reference

14 February 2019

Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

thymus development

determination method

1 reference

14 February 2019

Presenilins regulate alphabeta T cell development by modulating TCR signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

cell fate specification

determination method

1 reference

14 February 2019

gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

negative regulation of protein-containing complex assembly

determination method

1 reference

27 March 2018

An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

positive regulation of coagulation

determination method

1 reference

14 February 2019

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

neuron cellular homeostasis

determination method

1 reference

14 February 2019

Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

protein processing

determination method

4 references

14 February 2019

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

negative regulation of apoptotic signaling pathway

determination method

1 reference

14 February 2019

Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

protein maturation

determination method

1 reference

14 February 2019

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

negative regulation of protein binding

determination method

1 reference

27 March 2018

An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

endoplasmic reticulum calcium ion homeostasis

determination method

1 reference

14 February 2019

Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

amyloid-beta metabolic process

determination method

2 references

27 March 2018

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

27 March 2018

Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

regulation of synaptic plasticity

determination method

1 reference

14 February 2019

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

negative regulation of epidermal growth factor-activated receptor activity

determination method

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

membrane protein ectodomain proteolysis

determination method

3 references

embryonic limb morphogenesis

determination method

1 reference

14 February 2019

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

determination method

1 reference

14 February 2019

Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

negative regulation of ubiquitin-protein transferase activity

determination method

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

hematopoietic progenitor cell differentiation

determination method

1 reference

14 February 2019

Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method

1 reference

27 March 2018

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

regulation of epidermal growth factor-activated receptor activity

determination method

1 reference

14 February 2019

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

learning or memory

determination method

1 reference

14 February 2019

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

positive regulation of apoptotic process

determination method

1 reference

14 February 2019

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

protein transport

determination method

1 reference

14 February 2019

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

negative regulation of ubiquitin-dependent protein catabolic process

determination method

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

forebrain development

determination method

1 reference

14 February 2019

Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

dorsal/ventral neural tube patterning

determination method

1 reference

14 February 2019

Mice lacking both presenilin genes exhibit early embryonic patterning defects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

lung alveolus development

determination method

1 reference

14 February 2019

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

regulation of protein binding

determination method

1 reference

14 February 2019

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

T cell receptor signaling pathway

determination method

1 reference

14 February 2019

Presenilins regulate alphabeta T cell development by modulating TCR signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

positive regulation of receptor recycling

determination method

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

brain morphogenesis

determination method

1 reference

14 February 2019

Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

T cell activation involved in immune response

determination method

1 reference

14 February 2019

Presenilins regulate alphabeta T cell development by modulating TCR signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

Notch receptor processing

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

calcium ion transport

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

amyloid precursor protein catabolic process

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

amyloid-beta metabolic process

determination method

3 references

14 February 2019

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

determination method

regulation of calcium import into the mitochondrion

determination method

1 reference

14 January 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

mitochondrion-endoplasmic reticulum membrane tethering

determination method

1 reference

14 January 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000010753

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000010753

ENSMUSP00000106733

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000106733

ENSMUSP00000106734

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000106734

ENSMUSP00000106735

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000106735

ENSMUSP00000106737

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000106737

ENSMUSP00000120216

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000120216

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